Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes.
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Sulfamethoxazole induces a switch mechanism in T cell receptors containing TCRVβ20-1, altering pHLA recognitionEpitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complexDifferent Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors † ‡Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell ReceptorFluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing mannerT Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular FlexibilityA structural basis for antigen recognition by the T cell-like lymphocytes of sea lampreyCrystal Structures of HLA-A*0201 Complexed with Melan-A/MART-1 26(27L)-35 Peptidomimetics Reveal Conformational Heterogeneity and Highlight Degeneracy of T Cell RecognitionA highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHCConformational Melding Permits a Conserved Binding Geometry in TCR Recognition of Foreign and Self Molecular MimicsStructural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-ETCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct MechanismsMinimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimersDisparate Degrees of Hypervariable Loop Flexibility Control T-Cell Receptor Cross-Reactivity, Specificity, and Binding MechanismStructural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.Increased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking modeComputational Design of the Affinity and Specificity of a Therapeutic T Cell ReceptorModeling the ternary complex TCR-Vbeta/CollagenII(261-273)/HLA-DR4 associated with rheumatoid arthritisPeptide modulation of class I major histocompatibility complex protein molecular flexibility and the implications for immune recognition.IMPIPS: the immune protection-inducing protein structure concept in the search for steric-electron and topochemical principles for complete fully-protective chemically synthesised vaccine developmentThe effect of mutations on the alloreactive T cell receptor/peptide-MHC interface structure: a molecular dynamics study.Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.Understanding TR binding to pMHC complexes: how does a TR scan many pMHC complexes yet preferentially bind to one.TCRep 3D: an automated in silico approach to study the structural properties of TCR repertoires.The basis for limited specificity and MHC restriction in a T cell receptor interface.Evolving concepts of specificity in immune reactionsT-cell receptors binding orientation over peptide/MHC class I is driven by long-range interactionsStructural and dynamical insights on HLA-DR2 complexes that confer susceptibility to multiple sclerosis in Sardinia: a molecular dynamics simulation studyEarly relaxation dynamics in the LC 13 T cell receptor in reaction to 172 altered peptide ligands: a molecular dynamics simulation studyOn the logic of restrictive recognition of peptide by the T-cell antigen receptor.The Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor.The T-cell receptor is not hardwired to engage MHC ligands.Limitations of time-resolved fluorescence suggested by molecular simulations: assessing the dynamics of T cell receptor binding loops.Functional development of the T cell receptor for antigenHotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.αβ T cell receptor germline CDR regions moderate contact with MHC ligands and regulate peptide cross-reactivityTCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility.Structural and biophysical determinants of αβ T-cell antigen recognition.Structural and dynamic control of T-cell receptor specificity, cross-reactivity, and binding mechanism.Phage Display Engineered T Cell Receptors as Tools for the Study of Tumor Peptide-MHC Interactions.
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P2860
Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Conformational changes and fle ...... tion of peptide-MHC complexes.
@en
Conformational changes and fle ...... tion of peptide-MHC complexes.
@nl
type
label
Conformational changes and fle ...... tion of peptide-MHC complexes.
@en
Conformational changes and fle ...... tion of peptide-MHC complexes.
@nl
prefLabel
Conformational changes and fle ...... tion of peptide-MHC complexes.
@en
Conformational changes and fle ...... tion of peptide-MHC complexes.
@nl
P2093
P2860
P921
P356
P1433
P1476
Conformational changes and fle ...... tion of peptide-MHC complexes.
@en
P2093
Brian M Baker
Kathryn M Armstrong
Kurt H Piepenbrink
P275
P2860
P304
P356
10.1042/BJ20080850
P407
P577
2008-10-01T00:00:00Z
2008-10-15T00:00:00Z