A structural requirement for activation of skeletal ryanodine receptors by peptides of the dihydropyridine receptor II-III loop
about
The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha-helical dihydropyridine receptor segmentMolecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin AIdentification of a region of RyR1 that participates in allosteric coupling with the alpha(1S) (Ca(V)1.1) II-III loopTwo domains in dihydropyridine receptor activate the skeletal muscle Ca(2+) release channel.Arg(615)Cys substitution in pig skeletal ryanodine receptors increases activation of single channels by a segment of the skeletal DHPR II-III loopA component of excitation-contraction coupling triggered in the absence of the T671-L690 and L720-Q765 regions of the II-III loop of the dihydropyridine receptor alpha(1s) pore subunit.Structural determinants for activation or inhibition of ryanodine receptors by basic residues in the dihydropyridine receptor II-III loop.FKBP12 modulation of the binding of the skeletal ryanodine receptor onto the II-III loop of the dihydropyridine receptor.Scorpion venom components that affect ion-channels functionExcitation-contraction coupling from the 1950s into the new millennium.Multiple loops of the dihydropyridine receptor pore subunit are required for full-scale excitation-contraction coupling in skeletal muscle.Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins.Functional implications of modifying RyR-activating peptides for membrane permeability.Cyclization of the intrinsically disordered α1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function.Excitation-contraction coupling is unaffected by drastic alteration of the sequence surrounding residues L720-L764 of the alpha 1S II-III loop.Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling.Core skeletal muscle ryanodine receptor calcium release complex.The recombinant dihydropyridine receptor II-III loop and partly structured 'C' region peptides modify cardiac ryanodine receptor activity.The random-coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors.Peptide fragments of the dihydropyridine receptor can modulate cardiac ryanodine receptor channel activity and sarcoplasmic reticulum Ca2+ release.T-tubule depolarization-induced local events in the ryanodine receptor, as monitored with the fluorescent conformational probe incorporated by mediation of peptide A.Ca2+-dependent dual functions of peptide C. The peptide corresponding to the Glu724-Pro760 region (the so-called determinant of excitation-contraction coupling) of the dihydropyridine receptor alpha 1 subunit II-III loop.Multiple actions of imperatoxin A on ryanodine receptors: interactions with the II-III loop "A" fragment.
P2860
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P2860
A structural requirement for activation of skeletal ryanodine receptors by peptides of the dihydropyridine receptor II-III loop
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2000 nî lūn-bûn
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2000年の論文
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A structural requirement for a ...... opyridine receptor II-III loop
@ast
A structural requirement for a ...... opyridine receptor II-III loop
@en
A structural requirement for a ...... opyridine receptor II-III loop
@nl
type
label
A structural requirement for a ...... opyridine receptor II-III loop
@ast
A structural requirement for a ...... opyridine receptor II-III loop
@en
A structural requirement for a ...... opyridine receptor II-III loop
@nl
prefLabel
A structural requirement for a ...... opyridine receptor II-III loop
@ast
A structural requirement for a ...... opyridine receptor II-III loop
@en
A structural requirement for a ...... opyridine receptor II-III loop
@nl
P2093
P2860
P356
P1476
A structural requirement for a ...... opyridine receptor II-III loop
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P2093
P2860
P304
11631-11637
P356
10.1074/JBC.275.16.11631
P407
P577
2000-04-01T00:00:00Z