Excitation-contraction coupling is unaffected by drastic alteration of the sequence surrounding residues L720-L764 of the alpha 1S II-III loop.
about
Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscleFunctional analysis of a frame-shift mutant of the dihydropyridine receptor pore subunit (alpha1S) expressing two complementary protein fragmentsCa(V)1.1: The atypical prototypical voltage-gated Ca²⁺ channelThe three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha-helical dihydropyridine receptor segmentIdentification of a region of RyR1 that participates in allosteric coupling with the alpha(1S) (Ca(V)1.1) II-III loopA component of excitation-contraction coupling triggered in the absence of the T671-L690 and L720-Q765 regions of the II-III loop of the dihydropyridine receptor alpha(1s) pore subunit.Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractilityNon-Ca2+-conducting Ca2+ channels in fish skeletal muscle excitation-contraction coupling.Ryanodine modification of RyR1 retrogradely affects L-type Ca(2+) channel gating in skeletal muscle.The cardiac alpha(1C) subunit can support excitation-triggered Ca2+ entry in dysgenic and dyspedic myotubesCooperation of two-domain Ca(2+) channel fragments in triad targeting and restoration of excitation- contraction coupling in skeletal muscle.Imperatoxin a enhances Ca(2+) release in developing skeletal muscle containing ryanodine receptor type 3.The structure of Ca(2+) release units in arthropod body muscle indicates an indirect mechanism for excitation-contraction couplingRyR1/RyR3 chimeras reveal that multiple domains of RyR1 are involved in skeletal-type E-C couplingCardiac-type EC-coupling in dysgenic myotubes restored with Ca2+ channel subunit isoforms alpha1C and alpha1D does not correlate with current densityCa2+-dependent excitation-contraction coupling triggered by the heterologous cardiac/brain DHPR beta2a-subunit in skeletal myotubesInvolvement of a heptad repeat in the carboxyl terminus of the dihydropyridine receptor beta1a subunit in the mechanism of excitation-contraction coupling in skeletal muscleInteraction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction couplingMultiple loops of the dihydropyridine receptor pore subunit are required for full-scale excitation-contraction coupling in skeletal muscle.Transient loss of voltage control of Ca2+ release in the presence of maurocalcine in skeletal muscle.Functional implications of modifying RyR-activating peptides for membrane permeability.Cyclization of the intrinsically disordered α1S dihydropyridine receptor II-III loop enhances secondary structure and in vitro function.Rem uncouples excitation-contraction coupling in adult skeletal muscle fibers.Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunitEffects of inserting fluorescent proteins into the alpha1S II-III loop: insights into excitation-contraction coupling.Differential contribution of skeletal and cardiac II-III loop sequences to the assembly of dihydropyridine-receptor arrays in skeletal muscle.Reciprocal dihydropyridine and ryanodine receptor interactions in skeletal muscle activation.Ryanodine receptor calcium release channels: lessons from structure-function studies.The role of auxiliary subunits for the functional diversity of voltage-gated calcium channels.Physiological and pharmacological modulation of the embryonic skeletal muscle calcium channel splice variant CaV1.1eThe IQ motif is crucial for Cav1.1 functionStructural requirements of the dihydropyridine receptor alpha1S II-III loop for skeletal-type excitation-contraction coupling.The Ca2+ influx through the mammalian skeletal muscle dihydropyridine receptor is irrelevant for muscle performance.Proper restoration of excitation-contraction coupling in the dihydropyridine receptor beta1-null zebrafish relaxed is an exclusive function of the beta1a subunit.The alpha(1S) III-IV loop influences 1,4-dihydropyridine receptor gating but is not directly involved in excitation-contraction coupling interactions with the type 1 ryanodine receptor.Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1, revealing a proportional gating mechanism.The recombinant dihydropyridine receptor II-III loop and partly structured 'C' region peptides modify cardiac ryanodine receptor activity.The random-coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors.Peptide fragments of the dihydropyridine receptor can modulate cardiac ryanodine receptor channel activity and sarcoplasmic reticulum Ca2+ release.T-tubule depolarization-induced local events in the ryanodine receptor, as monitored with the fluorescent conformational probe incorporated by mediation of peptide A.
P2860
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P2860
Excitation-contraction coupling is unaffected by drastic alteration of the sequence surrounding residues L720-L764 of the alpha 1S II-III loop.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Excitation-contraction couplin ...... 4 of the alpha 1S II-III loop.
@ast
Excitation-contraction couplin ...... 4 of the alpha 1S II-III loop.
@en
type
label
Excitation-contraction couplin ...... 4 of the alpha 1S II-III loop.
@ast
Excitation-contraction couplin ...... 4 of the alpha 1S II-III loop.
@en
prefLabel
Excitation-contraction couplin ...... 4 of the alpha 1S II-III loop.
@ast
Excitation-contraction couplin ...... 4 of the alpha 1S II-III loop.
@en
P2093
P2860
P356
P1476
Excitation-contraction couplin ...... 64 of the alpha 1S II-III loop
@en
P2093
P2860
P304
P356
10.1073/PNAS.101618098
P407
P577
2001-04-24T00:00:00Z