Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II
about
The synaptic acetylcholinesterase tetramer assembles around a polyproline II helixNovel splice isoforms for NLGN3 and NLGN4 with possible implications in autismNovel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticidesStructural insights into ligand interactions at the acetylcholinesterase peripheral anionic site.Freeze-frame inhibitor captures acetylcholinesterase in a unique conformationAcetylcholinesterase: From 3D structure to functionEffect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevityA wrench in the works of human acetylcholinesterase: soman induced conformational changes revealed by molecular dynamics simulationsAn integrated approach with new strategies for QSAR models and lead optimization.Effect of human acetylcholinesterase subunit assembly on its circulatory residenceSelective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides.Dual binding site and selective acetylcholinesterase inhibitors derived from integrated pharmacophore models and sequential virtual screening.Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions.Recent advances toward a general purpose linear-scaling quantum force fieldThe discovery of potential acetylcholinesterase inhibitors: a combination of pharmacophore modeling, virtual screening, and molecular docking studies.Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traitsCrystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site: evidence for open and closed states of a back door channel.Inhibition of acetylcholinesterase by two genistein derivatives: kinetic analysis, molecular docking and molecular dynamics simulationSynthesis and in silico evaluation of 1N-methyl-1S-methyl-2-nitroethylene (NMSM) derivatives against Alzheimer disease: to understand their interacting mechanism with acetylcholinesterase.Dynamics of the acetylcholinesterase tetramer.Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) studyChemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase.High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays.Development of an in-vivo active reversible butyrylcholinesterase inhibitor.Nature: a substantial source of auspicious substances with acetylcholinesterase inhibitory action.How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies.Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer's disease.Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence.Reaction pathways and free energy profiles for cholinesterase-catalyzed hydrolysis of 6-monoacetylmorphine.The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complexStructural insights into substrate traffic and inhibition in acetylcholinesteraseBisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.Reaction pathway and free-energy barrier for reactivation of dimethylphosphoryl-inhibited human acetylcholinesteraseReaction profiles of the interaction between sarin and acetylcholinesterase and the S203C mutant: model nucleophiles and QM/MM potential energy surfacesDesign, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase.Weak conservation of structural features in the interfaces of homologous transient protein-protein complexes.Butyrylcholinesterase and G116H, G116S, G117H, G117N, E197Q and G117H/E197Q mutants: a molecular dynamics study.Active site gating and substrate specificity of butyrylcholinesterase and acetylcholinesterase: insights from molecular dynamics simulations.New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.AcCho is hydrolyzed to Cho and acetate by ACHE
P2860
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P2860
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II
description
2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
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2000年论文
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name
Structures of recombinant nati ...... nake-venom toxin fasciculin-II
@ast
Structures of recombinant nati ...... nake-venom toxin fasciculin-II
@en
Structures of recombinant nati ...... nake-venom toxin fasciculin-II
@nl
type
label
Structures of recombinant nati ...... nake-venom toxin fasciculin-II
@ast
Structures of recombinant nati ...... nake-venom toxin fasciculin-II
@en
Structures of recombinant nati ...... nake-venom toxin fasciculin-II
@nl
prefLabel
Structures of recombinant nati ...... nake-venom toxin fasciculin-II
@ast
Structures of recombinant nati ...... nake-venom toxin fasciculin-II
@en
Structures of recombinant nati ...... nake-venom toxin fasciculin-II
@nl
P2093
P1476
Structures of recombinant nati ...... ake-venom toxin fasciculin-II.
@en
P2093
A Shafferman
J L Sussman
P304
P577
2000-11-01T00:00:00Z