Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation - Wikidata - awgldk - TriplyDB

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

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Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design Crystal Structure of Thioflavin T Bound to the Peripheral Site of Torpedo californica Acetylcholinesterase Reveals How Thioflavin T Acts as a Sensitive Fluorescent Reporter of Ligand Binding to the Acylation Site Conformational Remodeling of Femtomolar Inhibitor−Acetylcholinesterase Complexes in the Crystalline State Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor Molecular characterization of monoclonal antibodies that inhibit acetylcholinesterase by targeting the peripheral site and backdoor region Similar but different: thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesterase Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oxime Kinetic target-guided synthesis in drug discovery and chemical biology: a comprehensive facts and figures survey AutoClickChem: click chemistry in silico Molecular recognition of rosmarinic acid from Salvia sclareoides extracts by acetylcholinesterase: a new binding site detected by NMR spectroscopy.Accurate MALDI-TOF/TOF sequencing of one-bead-one-compound peptide libraries with application to the identification of multiligand protein affinity agents using in situ click chemistry screening Probing gorge dimensions of cholinesterases by freeze-frame click chemistry.N-acetylcholinesterase-induced apoptosis in Alzheimer's disease Screening of protein-protein interaction modulators via sulfo-click kinetic target-guided synthesis e-LEA3D: a computational-aided drug design web server Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms.Expanding the palette of phenanthridinium cations.In situ click chemistry: a powerful means for lead discovery.1,4-linked 1,2,3-Triazole des-peptidic analogues of PNA (TzNA): Synthesis of TzNA oligomers by "click" reaction on solid phase and stabilization of derived triplexes with DNA Crystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site: evidence for open and closed states of a back door channel.Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.Transition-metal-catalyzed denitrogenative transannulation: converting triazoles into other heterocyclic systems.Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates.Neurotoxicology of bis(n)-tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase.Targeting acetylcholinesterase to treat neurodegeneration.Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics.Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes.Direct Pd-catalyzed arylation of 1,2,3-triazoles Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase.Iterative in situ click chemistry creates antibody-like protein-capture agents.Amyloid-cholinesterase interactions. Implications for Alzheimer's disease.Highly enantioselective dearomatizing formal [3+3] cycloaddition reactions of N-acyliminopyridinium ylides with electrophilic enol carbene intermediates.A proposal for the revision of molecular boundary typology.New insights into the kinetic target-guided synthesis of protein ligands.Computational Studies on Acetylcholinesterases.Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches.

P2860

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P2860

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

http://www.wikidata.org/entity/Q27643075

description

2004 nî lūn-bûn

@nan

2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի փետրվարին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

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Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

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Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

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type

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Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

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Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

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Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

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prefLabel

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

@ast

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

@en

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

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PNAS.0308206100

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

@en

P2093

Hartmuth C Kolb

http://www.w3.org/2001/XMLSchema#string

Palmer Taylor

http://www.w3.org/2001/XMLSchema#string

Zoran Radić

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P2860

Acetylcholinesterase--new roles for an old actor

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase

Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

PROCHECK: a program to check the stereochemical quality of protein structures

Processing of X-ray diffraction data collected in oscillation mode

Conformational flexibility of the acetylcholinesterase tetramer suggested by x-ray crystallography

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam

Structural mechanisms of QacR induction and multidrug recognition

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1449-54

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scholarly article

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10.1073/PNAS.0308206100

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6

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101

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Karl Barry Sharpless

Pascale Marchot

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2004-02-10T00:00:00Z

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8890290

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341740

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