Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine - Wikidata - awgldk - TriplyDB

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

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The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A Structural and functional diversity of the microbial kinome The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling Rapamycin and mTOR kinase inhibitors PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors The Inositide Signaling Pathway As a Target for Treating Gastric Cancer and Colorectal Cancer Myricetin: A Dietary Molecule with Diverse Biological Activities Anticancer Properties of Phyllanthus emblica (Indian Gooseberry)Design principles underpinning the regulatory diversity of protein kinases Is Wortmannin-Induced Reorganization of the trans-Golgi Network the Key to Explain Charasome Formation?Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant Tick-borne encephalitis virus replication, intracellular trafficking, and pathogenicity in human intestinal Caco-2 cell monolayers African swine fever virus uses macropinocytosis to enter host cells Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations Structure-Based Design of an Organoruthenium Phosphatidyl-inositol-3-kinase Inhibitor Reveals a Switch Governing Lipid Kinase Potency and Selectivity Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis A frequent kinase domain mutation that changes the interaction between PI3K and the membrane The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1 Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor.Structural and functional analysis of the natural JNK1 inhibitor quercetagetin Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Å resolution Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors Complex gadolinium-oxo clusters formed along concave protein surfaces Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)A fast topological analysis algorithm for large-scale similarity evaluations of ligands and binding pockets Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents Molecular Mechanisms and Metabolomics of Natural Polyphenols Interfering with Breast Cancer Metastasis Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo Flavonoids: modulators of brain function?Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone PI3K/PTEN signaling in angiogenesis and tumorigenesis

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

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2000 nî lūn-bûn

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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2000 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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Structural Determinants of Pho ...... , Myricetin, and Staurosporine

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Structural determinants of pho ...... , myricetin, and staurosporine

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Structural Determinants of Pho ...... , Myricetin, and Staurosporine

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Structural Determinants of Pho ...... , Myricetin, and Staurosporine

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Structural determinants of pho ...... , myricetin, and staurosporine

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Structural Determinants of Pho ...... , Myricetin, and Staurosporine

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Structural Determinants of Pho ...... , Myricetin, and Staurosporine

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Structural determinants of pho ...... , myricetin, and staurosporine

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