Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases - Wikidata - awgldk - TriplyDB

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

http://www.wikidata.org/entity/Q27652488

about

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2 Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide Targeting the mTOR kinase domain: the second generation of mTOR inhibitors Selectivity and therapeutic inhibition of kinases: to be or not to be?Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders Targeting LKB1 in cancer - exposing and exploiting vulnerabilities Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectives A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11 The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1 mTOR kinase structure, mechanism and regulation Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo Discovery of Diverse Small-Molecule Inhibitors of Mammalian Sterile20-like Kinase 3 (MST3)A multi-label approach to target prediction taking ligand promiscuity into account Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders mTOR inhibitors in cancer therapy Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90 The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing Mining significant substructure pairs for interpreting polypharmacology in drug-target network Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir Using multiple microenvironments to find similar ligand-binding sites: application to kinase inhibitor binding Bioorthogonal small molecule imaging agents allow single-cell imaging of MET In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis Targeting the phosphoinositide 3-kinase pathway in cancer Divergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors.Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase Activating mutations in TOR are in similar structures as oncogenic mutations in PI3KCalpha.Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.Polypharmacology in Precision Oncology: Current Applications and Future Prospects Identification of gefitinib off-targets using a structure-based systems biology approach; their validation with reverse docking and retrospective data mining Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor Hybrid dual aromatase-steroid sulfatase inhibitors with exquisite picomolar inhibitory activity.Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity.Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway.Discovery of biarylaminoquinazolines as novel tubulin polymerization inhibitors Targeting the cancer kinome through polypharmacology.Quantitative network mapping of the human kinome interactome reveals new clues for rational kinase inhibitor discovery and individualized cancer therapy

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P2860

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

http://www.wikidata.org/entity/Q27652488

description

2008 nî lūn-bûn

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2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Targeted polypharmacology: dis ...... e and phosphoinositide kinases

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Targeted polypharmacology: dis ...... e and phosphoinositide kinases

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Targeted polypharmacology: dis ...... e and phosphoinositide kinases

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Targeted polypharmacology: dis ...... e and phosphoinositide kinases

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Targeted polypharmacology: dis ...... e and phosphoinositide kinases

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Targeted polypharmacology: dis ...... e and phosphoinositide kinases

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Targeted polypharmacology: dis ...... e and phosphoinositide kinases

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Targeted polypharmacology: dis ...... e and phosphoinositide kinases

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Targeted polypharmacology: dis ...... e and phosphoinositide kinases

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Nature Chemical Biology

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Targeted polypharmacology: dis ...... e and phosphoinositide kinases

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Beth Apsel

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Brian Aizenstein

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Jimmy A Blair

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Kevan M Shokat

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Morri E Feldman

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Randy Hoffman

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P2860

Structural evolution of the protein kinase-like superfamily

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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691-699

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scholarly article

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2828047

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10.1038/NCHEMBIO.117

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11

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4

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Roger L. Williams

Zachary A Knight

Beatriz González

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2008-10-12T00:00:00Z

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232776721

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1016767348

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18849971

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2880455

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