Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases
about
Enzymes of the cyclooxygenase pathways of prostanoid biosynthesisHuman cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimerStructure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1Structural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2The Structural Basis of Endocannabinoid Oxygenation by Cyclooxygenase-2Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVERole of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2Molecular dynamics simulations of arachidonic acid complexes with COX-1 and COX-2: insights into equilibrium behaviorPartnering between monomers of cyclooxygenase-2 homodimersCrystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.Prostaglandin H synthase: resolved and unresolved mechanistic issues.Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.Characterization of free radicals formed from COX-catalyzed DGLA peroxidation.Pharmacophore elucidation and molecular docking studies on 5-phenyl-1-(3-pyridyl)-1h-1,2,4-triazole-3-carboxylic acid derivatives as COX-2 inhibitors.His-311 and Arg-559 are key residues involved in fatty acid oxygenation in pathogen-inducible oxygenase.Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.Diarylheterocycle Core Ring Features Effect in Selective COX-1 Inhibition
P2860
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P2860
Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases
description
2001 nî lūn-bûn
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2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年论文
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name
Mutational and X-ray crystallo ...... andin endoperoxide H synthases
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Mutational and X-ray crystallo ...... andin endoperoxide H synthases
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Mutational and X-ray crystallo ...... andin endoperoxide H synthases
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type
label
Mutational and X-ray crystallo ...... andin endoperoxide H synthases
@ast
Mutational and X-ray crystallo ...... andin endoperoxide H synthases
@en
Mutational and X-ray crystallo ...... andin endoperoxide H synthases
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prefLabel
Mutational and X-ray crystallo ...... andin endoperoxide H synthases
@ast
Mutational and X-ray crystallo ...... andin endoperoxide H synthases
@en
Mutational and X-ray crystallo ...... andin endoperoxide H synthases
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P2093
P2860
P356
P1476
Mutational and X-ray crystallo ...... andin endoperoxide H synthases
@en
P2093
A M Mulichak
E D Thuresson
K M Lakkides
M G Malkowski
R M Garavito
S L Ginell
P2860
P304
P356
10.1074/JBC.M009378200
P407
P577
2001-03-30T00:00:00Z