Prostaglandin H synthase: resolved and unresolved mechanistic issues.
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Enzymes of the cyclooxygenase pathways of prostanoid biosynthesisHuman cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimerReversible Phenol Oxidation and Reduction in the Structurally Well-Defined 2-Mercaptophenol-α 3 C ProteinRedox properties of tyrosine and related moleculesA Radical Transfer Pathway in Spore Photoproduct LyaseRedox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobinHeme enzyme structure and function.A Revised Mechanism for Human Cyclooxygenase-2.A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatusEnzyme reactivation by hydrogen peroxide in heme-based tryptophan dioxygenaseThe role of nitric oxide in prostaglandin biology; update.Human cyclooxygenase-1 activity and its responses to COX inhibitors are allosterically regulated by nonsubstrate fatty acids.Decreased cyclooxygenase inhibition by aspirin in polymorphic variants of human prostaglandin H synthase-1.Inhibition of heme peroxidases by melamine.Different Fatty Acids Compete with Arachidonic Acid for Binding to the Allosteric or Catalytic Subunits of Cyclooxygenases to Regulate Prostanoid Synthesis.Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.Unique coupling of mono- and dioxygenase chemistries in a single active site promotes heme degradation.Interactions of 2-O-arachidonylglycerol ether and ibuprofen with the allosteric and catalytic subunits of human COX-2.Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an ExampleSubstrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide TonePre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.OH cleavage from tyrosine: debunking a mythIncorporation of fluorotyrosines into ribonucleotide reductase using an evolved, polyspecific aminoacyl-tRNA synthetase.In Silico Screening of Nonsteroidal Anti-Inflammatory Drugs and Their Combined Action on Prostaglandin H Synthase-1.Reverse Electron Transfer Completes the Catalytic Cycle in a 2,3,5-Trifluorotyrosine-Substituted Ribonucleotide Reductase.Formal reduction potential of 3,5-difluorotyrosine in a structured protein: insight into multistep radical transfer.Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects.Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins.Aspirin as a COX inhibitor and anti-inflammatory drug in human skeletal muscle.Formal Reduction Potentials of Difluorotyrosine and Trifluorotyrosine Protein Residues: Defining the Thermodynamics of Multistep Radical Transfer.Arteriolar oxygen reactivity: where is the sensor and what is the mechanism of action?Hydrogen bond donating ability of meta and para hydroxy phenoxyl radicalsInfluence of Substrate Dideuteration on the Reaction of the Bifunctional Heme Enzyme Psi Factor Producing Oxygenase A (PpoA)
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Prostaglandin H synthase: resolved and unresolved mechanistic issues.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Prostaglandin H synthase: resolved and unresolved mechanistic issues.
@en
Prostaglandin H synthase: resolved and unresolved mechanistic issues.
@nl
type
label
Prostaglandin H synthase: resolved and unresolved mechanistic issues.
@en
Prostaglandin H synthase: resolved and unresolved mechanistic issues.
@nl
prefLabel
Prostaglandin H synthase: resolved and unresolved mechanistic issues.
@en
Prostaglandin H synthase: resolved and unresolved mechanistic issues.
@nl
P2860
P1476
Prostaglandin H synthase: resolved and unresolved mechanistic issues.
@en
P2093
Ah-Lim Tsai
Richard J Kulmacz
P2860
P304
P356
10.1016/J.ABB.2009.08.019
P407
P577
2009-09-01T00:00:00Z