The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition
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Microfibrillar structure of type I collagen in situX-ray structure of a novel matrix metalloproteinase inhibitor complexed to stromelysinDeterminants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analoguesDiscovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effectsStructural insights into triple-helical collagen cleavage by matrix metalloproteinase 1Structural Basis for Matrix Metalloproteinase-2 (MMP-2)-selective Inhibitory Action of -Amyloid Precursor Protein-derived InhibitorInsights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculationsThe roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity.High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.Let's not forget tautomers.Matrix metalloproteinases and collagen catabolism.Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases.Tautomerism in computer-aided drug design.Ambit-Tautomer: An Open Source Tool for Tautomer Generation.Tautomerism and magnesium chelation of HIV-1 integrase inhibitors: a theoretical study.Anthocyanins and their role in cancer prevention.Chemistry, Pharmacology and Health Benefits of Anthocyanins.Molecular design of a highly selective and strong protein inhibitor against matrix metalloproteinase-2 (MMP-2).Computational insights into the selectivity mechanism of APP-IP over matrix metalloproteinases.Identification of a region of beta-amyloid precursor protein essential for its gelatinase A inhibitory activity.Syntheses of Radioiodinated Pyrimidine-2,4,6-Triones as Potential Agents for Non-Invasive Imaging of Matrix Metalloproteinases.Thioredoxin fusion construct enables high-yield production of soluble, active matrix metalloproteinase-8 (MMP-8) in Escherichia coli.Direct Synthesis of 5-Aryl Barbituric Acids by Rhodium(II)-Catalyzed Reactions of Arenes with Diazo Compounds.Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors.The collagenolytic action of MMP-1 is regulated by the interaction between the catalytic domain and the hinge region.Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3' subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond.Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage.Radiofluorinated pyrimidine-2,4,6-triones as molecular probes for noninvasive MMP-targeted imaging.
P2860
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P2860
The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The 1.8-A crystal structure of ...... lagenase substrate recognition
@ast
The 1.8-A crystal structure of ...... lagenase substrate recognition
@en
The 1.8-A crystal structure of ...... lagenase substrate recognition
@nl
type
label
The 1.8-A crystal structure of ...... lagenase substrate recognition
@ast
The 1.8-A crystal structure of ...... lagenase substrate recognition
@en
The 1.8-A crystal structure of ...... lagenase substrate recognition
@nl
prefLabel
The 1.8-A crystal structure of ...... lagenase substrate recognition
@ast
The 1.8-A crystal structure of ...... lagenase substrate recognition
@en
The 1.8-A crystal structure of ...... lagenase substrate recognition
@nl
P2093
P2860
P356
P1476
The 1.8-A crystal structure of ...... lagenase substrate recognition
@en
P2093
P2860
P304
17405-17412
P356
10.1074/JBC.M007475200
P407
P577
2001-01-22T00:00:00Z