Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3' subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond.
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A cancer cell metalloprotease triad regulates the basement membrane transmigration programMatrix metalloproteinase interactions with collagen and elastinLPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activityNetwork analyses reveal pervasive functional regulation between proteases in the human protease webRemote exosites of the catalytic domain of matrix metalloproteinase-12 enhance elastin degradation.Path to Collagenolysis: COLLAGEN V TRIPLE-HELIX MODEL BOUND PRODUCTIVELY AND IN ENCOUNTERS BY MATRIX METALLOPROTEINASE-12.The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity.High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.Proteomic protease specificity profiling of clostridial collagenases reveals their intrinsic nature as dedicated degraders of collagen.Direct visualization of protease action on collagen triple helical structure.NMR and bioinformatics discovery of exosites that tune metalloelastase specificity for solubilized elastin and collagen triple helices.Basis for substrate recognition and distinction by matrix metalloproteinasesTruncated active human matrix metalloproteinase-8 delivered by a chimeric adenovirus-hepatitis B virus vector ameliorates rat liver cirrhosis.TIMP independence of matrix metalloproteinase (MMP)-2 activation by membrane type 2 (MT2)-MMP is determined by contributions of both the MT2-MMP catalytic and hemopexin C domains.Exosite interactions impact matrix metalloproteinase collagen specificities.Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2).Insight towards the conserved water mediated recognition of catalytic and structural Zn(+2) ions in human Matrix Metalloproteinase-8 enzyme: A study by MD-simulation methodsActive site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.Interstitial collagen catabolism.Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-ProTriple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors.Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences.Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity.The role of collagen charge clusters in the modulation of matrix metalloproteinase activity.MMP-12 catalytic domain recognizes triple helical peptide models of collagen V with exosites and high activity.Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella.Increased Neuronal Depolarization Evoked by Autoantibodies in Diabetic Obstructive Sleep Apnea: Role for Inflammatory Protease(s) in Generation of Neurotoxic Immunoglobulin Fragment.
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P2860
Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3' subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Pivotal molecular determinants ...... 9 and the connecting cis bond.
@en
Pivotal molecular determinants ...... of matrix metalloproteinase 8
@nl
type
label
Pivotal molecular determinants ...... 9 and the connecting cis bond.
@en
Pivotal molecular determinants ...... of matrix metalloproteinase 8
@nl
prefLabel
Pivotal molecular determinants ...... 9 and the connecting cis bond.
@en
Pivotal molecular determinants ...... of matrix metalloproteinase 8
@nl
P2860
P356
P1476
Pivotal molecular determinants ...... 9 and the connecting cis bond.
@en
P2093
Charlotte J Morrison
Gayle R Pelman
P2860
P304
P356
10.1074/JBC.M409603200
P407
P577
2004-11-08T00:00:00Z