Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
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Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors.Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformationThe R163K Mutant of Human Thymidylate Synthase Is Stabilized in an Active Conformation: Structural Asymmetry and Reactivity of Cysteine 195 † ‡Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability,Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand bindingProtein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthaseStructure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of BrivudineThe intrinsically disordered N-terminal domain of thymidylate synthase targets the enzyme to the ubiquitin-independent proteasomal degradation pathwayDistribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine.Targeting a regulatory element in human thymidylate synthase mRNA.Analysis of mRNA recognition by human thymidylate synthase.Advances in the REDCAT software package.Cooperation between an intrinsically disordered region and a helical segment is required for ubiquitin-independent degradation by the proteasomeConservation and Role of Electrostatics in Thymidylate Synthase.Characterization of the bipartite degron that regulates ubiquitin-independent degradation of thymidylate synthase.Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductaseA potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase.Preserved hydride transfer mechanism in evolutionarily divergent thymidylate synthases.Role of long-range protein dynamics in different thymidylate synthase catalyzed reactions.Dimer-monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transferRole of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase.Activation of Two Sequential H-transfers in the Thymidylate Synthase Catalyzed Reaction.Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles.Molecular docking studies on quinazoline antifolate derivatives as human thymidylate synthase inhibitors.Role of Y94 in proton and hydride transfers catalyzed by thymidylate synthase.Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation.The general base in the thymidylate synthase catalyzed proton abstraction.dUMP + N5;N10-methylene tetrahydrofolate => TMP + dihydrofolateStructural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach.New Insight into the Octamer of TYMS Stabilized by Intermolecular Cys43-Disulfide.
P2860
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P2860
Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors
description
2001 nî lūn-bûn
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2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
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2001年论文
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name
Structure of human thymidylate ...... with noncompetitive inhibitors
@ast
Structure of human thymidylate ...... with noncompetitive inhibitors
@en
Structure of human thymidylate ...... with noncompetitive inhibitors
@nl
type
label
Structure of human thymidylate ...... with noncompetitive inhibitors
@ast
Structure of human thymidylate ...... with noncompetitive inhibitors
@en
Structure of human thymidylate ...... with noncompetitive inhibitors
@nl
prefLabel
Structure of human thymidylate ...... with noncompetitive inhibitors
@ast
Structure of human thymidylate ...... with noncompetitive inhibitors
@en
Structure of human thymidylate ...... with noncompetitive inhibitors
@nl
P2093
P2860
P921
P356
P1476
Structure of human thymidylate ...... with noncompetitive inhibitors
@en
P2093
D J Steadman
R B Dunlap
S H Berger
P2860
P304
P356
10.1074/JBC.M009493200
P407
P50
P577
2001-04-27T00:00:00Z