Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain - Wikidata - awgldk - TriplyDB

Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain

Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain

http://www.wikidata.org/entity/Q27637088

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Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor gene Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304 Mouse models of neurofibromatosis 1 and 2.Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex.Structural Basis for CD44 Recognition by ERM Proteins Structural Basis of Tumor Suppressor in Lung Cancer 1 (TSLC1) Binding to Differentially Expressed in Adenocarcinoma of the Lung (DAL-1/4.1B)Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor Structural Basis of the Binding of Merlin FERM Domain to the E3 Ubiquitin Ligase Substrate Adaptor DCAF1 Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function Molecular conformation of the full-length tumor suppressor NF2/Merlin--a small-angle neutron scattering study Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival Crystal structure of the FERM domain of focal adhesion kinase.NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations.FERM domain interaction promotes FAK signaling.Missense mutations in the NF2 gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic function.A FERM-adjacent (FA) region defines a subset of the 4.1 superfamily and is a potential regulator of FERM domain function.Fluorescence resonance energy transfer analysis of merlin conformational changes.p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway FERM domain phosphoinositide binding targets merlin to the membrane and is essential for its growth-suppressive function.Membrane recognition and targeting by lipid-binding domains.Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain.Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.Topographical significance of membrane skeletal component protein 4.1 B in mammalian organs.Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing Structural and functional insights into the TEAD-YAP complex in the Hippo signaling pathway.Novel mutation c.980_983delATTA compound with c.986C>A mutation of the FRMD7 gene in a Chinese family with X-linked idiopathic congenital nystagmus Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex.Merlin: the wizard requires protein stability to function as a tumor suppressor.Merlin, the NF2 gene product.Molecular insights into NF2/Merlin tumor suppressor function.Hippo-YAP signaling pathway: A new paradigm for cancer therapy.Protein 4.1R Influences Myogenin Protein Stability and Skeletal Muscle Differentiation.Schwannomas exhibit distinct size-dependent gene-expression patterns.Overexpression of ezrin inactivates NF2 tumor suppressor in glioblastoma.Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin.

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P2860

Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain

http://www.wikidata.org/entity/Q27637088

description

2002 nî lūn-bûn

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2002 թուականի Մարտին հրատարակուած գիտական յօդուած

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2002 թվականի մարտին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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Structural basis for neurofibr ...... ture of the merlin FERM domain

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Structural basis for neurofibr ...... ture of the merlin FERM domain

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Structural basis for neurofibr ...... ture of the merlin FERM domain

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Structural basis for neurofibr ...... ture of the merlin FERM domain

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Structural basis for neurofibr ...... ture of the merlin FERM domain

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Structural basis for neurofibr ...... ture of the merlin FERM domain

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Structural basis for neurofibr ...... ture of the merlin FERM domain

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Structural basis for neurofibr ...... ture of the merlin FERM domain

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Structural basis for neurofibr ...... ture of the merlin FERM domain

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P1433

Journal of Biological Chemistry

P1476

Structural basis for neurofibr ...... ture of the merlin FERM domain

@en

P2093

Azusa Seto

http://www.w3.org/2001/XMLSchema#string

Keisuke Hamada

http://www.w3.org/2001/XMLSchema#string

Nobuo Maita

http://www.w3.org/2001/XMLSchema#string

Sachiko Tsukita

http://www.w3.org/2001/XMLSchema#string

Shoichiro Tsukita

http://www.w3.org/2001/XMLSchema#string

Toshio Hakoshima

http://www.w3.org/2001/XMLSchema#string

Toshiyuki Shimizu

http://www.w3.org/2001/XMLSchema#string

P2860

Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins

Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization.

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

PROCHECK: a program to check the stereochemical quality of protein structures

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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10332-6

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scholarly article

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10.1074/JBC.M109979200

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12

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277

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2002-03-22T00:00:00Z

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11756419

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crystal structure