Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding
about
Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesisStructural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug developmentBiosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinaseStructures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysisStructure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycinStructures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate ComplexesInhibition of 1-Deoxy- d -Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic StudiesMolecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparumCrystal Structure of Brucella abortus Deoxyxylulose-5-phosphate Reductoisomerase-like (DRL) Enzyme Involved in Isoprenoid BiosynthesisAntimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5-phosphate ReductoisomeraseAlteration of the Flexible Loop in 1-Deoxy- d -xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by FosmidomycinIsoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasitesLethal mutations in the isoprenoid pathway of Salmonella entericaMevalonate and nonmevalonate pathways for the biosynthesis of isoprene units.Terpene Specialized Metabolism in Arabidopsis thalianaThermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate ReductoisomeraseTargeting the formation of the cell wall core of M. tuberculosis.The non-mevalonate pathway of isoprenoid precursor biosynthesis.Inhibition Studies on Enzymes Involved in Isoprenoid Biosynthesis: Focus on Two Potential Drug Targets: DXR and IDI-2 Enzymes.Mechanistic aspects of carotenoid biosynthesis.Biochemistry of the non-mevalonate isoprenoid pathway.Crystallization and preliminary X-ray crystallographic study of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Plasmodium falciparum.Conformational dynamics of the flexible catalytic loop in Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.The role of phosphate in a multistep enzymatic reaction: reactions of the substrate and intermediate in piecesIsoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase.A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues.NMR studies of DOXP reductoisomerase and its inhibitor complex.The chemical mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase from Escherichia coli.The MEP pathway and the development of inhibitors as potential anti-infective agents
P2860
Q27023526-905BE741-602D-4398-8E98-37D807A2E1DBQ27640632-5B84988D-C07D-4EEF-8CD8-309ECB64F41AQ27641732-38634599-D36F-43B4-9988-7F5BF012A2A6Q27644732-7203C16B-059E-4B45-8A3E-F67284502586Q27645328-6BD230C3-FC0B-4065-90B5-90C5170CA0A7Q27667195-D5560463-2BBD-4362-A09F-A37DC14000EDQ27667791-93CD5CB7-1F7F-4C3B-9463-A1CF5F762643Q27677409-DE05D2E7-EA1F-4C3E-AE2C-CC6750E5BAD8Q27678168-DC5534DF-9957-40E7-BBA6-4636CF7F41F1Q27678753-501460E8-B88B-446C-BCB7-04F5D6309534Q27683779-4F62F2BC-C1F5-4E59-9C92-43D3AC6D8180Q28727252-185CC06C-9717-45E2-A764-EFE1A8728232Q34353900-647F1360-F89D-428F-B338-5E823ACBB8D8Q34919858-026B50CF-65B5-4548-80F9-451B81AA97E7Q35710557-8F75FCAE-61F3-470B-8DCB-D1EA46E788CBQ36290683-76DAF7AF-EAED-4D23-879E-1743E8FB7A34Q36561313-9E3190C3-46A6-466B-8A2A-04B40D08E760Q36795133-E59DC079-34B0-4067-97DA-5E1F8BBE036CQ37377126-D452F1F2-4706-4C78-99E5-865FA625D249Q37503777-566D9A88-9BC2-4CE0-82AB-5A455BC8D772Q37899789-74DAAF6A-C305-487D-9B75-298FA463FBFCQ39433816-ADB7AF08-6AE7-4D71-BA2E-61E569B7E7A2Q41914185-FEA3287E-7819-4E32-BC34-6D062F898A95Q42358832-AFE2A6D4-E38A-41C1-A3FE-77CB0217C1F3Q44135931-ECCB266B-CE9E-4089-82C1-A9E7AFAC165AQ46664564-73A6036A-49A7-4D10-899C-E889877AFCA2Q47842955-475A982D-4EB2-41C0-9240-8352926B1606Q47971312-D0F37033-7482-40EA-A43E-46249F494B17Q54441015-076338E7-ECE3-413C-95E4-EF91DAEF2816Q56994497-5E3AF78B-498F-465E-9F77-19282BA89B43
P2860
Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Crystal structure of 1-deoxy-D ...... ovement upon substrate binding
@ast
Crystal structure of 1-deoxy-D ...... ovement upon substrate binding
@en
Crystal structure of 1-deoxy-D ...... ovement upon substrate binding
@nl
type
label
Crystal structure of 1-deoxy-D ...... ovement upon substrate binding
@ast
Crystal structure of 1-deoxy-D ...... ovement upon substrate binding
@en
Crystal structure of 1-deoxy-D ...... ovement upon substrate binding
@nl
prefLabel
Crystal structure of 1-deoxy-D ...... ovement upon substrate binding
@ast
Crystal structure of 1-deoxy-D ...... ovement upon substrate binding
@en
Crystal structure of 1-deoxy-D ...... ovement upon substrate binding
@nl
P2093
P1476
Crystal structure of 1-deoxy-D ...... ovement upon substrate binding
@en
P2093
Haruo Seto
Kanju Ohsawa
Shunsuke Yajima
Takamasa Nonaka
Tomohisa Kuzuyama
P356
10.1093/OXFORDJOURNALS.JBCHEM.A003105
P577
2002-03-01T00:00:00Z