Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase - Wikidata - awgldk - TriplyDB

Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase

Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase

http://www.wikidata.org/entity/Q27641732

about

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase Structures of Staphylococcus aureus D-tagatose-6-phosphate kinase implicate domain motions in specificity and mechanism Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl-d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery Structure of the Ternary Complex of Phosphomevalonate Kinase: The Enzyme and Its Family A triclinic crystal form ofEscherichia coli4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure Structural Basis for Nucleotide Binding and Reaction Catalysis in Mevalonate Diphosphate Decarboxylase IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens.Comparison of the transcriptomes of ginger (Zingiber officinale Rosc.) and mango ginger (Curcuma amada Roxb.) in response to the bacterial wilt infection Synthetic Routes to Methylerythritol Phosphate Pathway Intermediates and Downstream Isoprenoids.Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria.Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica Innovative therapy for Classic Galactosemia - tale of two HTS.Lethal mutations in the isoprenoid pathway of Salmonella enterica Crystallization and preliminary X-ray analysis of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis.Terpene Specialized Metabolism in Arabidopsis thaliana The plastid-derived organelle of protozoan human parasites as a target of established and emerging drugs.Formal Synthesis of 4-diphosphocytidyl-2-C-methyl D-erythritol From D-(+)-Arabitol.Targeting the formation of the cell wall core of M. tuberculosis.Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents The non-mevalonate pathway of isoprenoid precursor biosynthesis.The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.Mechanistic aspects of carotenoid biosynthesis.Biochemistry of the non-mevalonate isoprenoid pathway.Molecular recognition in chemical and biological systems.Metabolic engineering for isoprenoid-based biofuel production.Inhibitors interacting with the magnesium binding site of reverse transcriptase: synthesis and biological activity studies of 3'-(omega-amino-acyl) amino-3'-deoxy-thymidine.A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate.A preliminary crystallographic analysis of the putative mevalonate diphosphate decarboxylase from Trypanosoma brucei.Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway.Alteration of oligomeric state and domain architecture is essential for functional transformation between transferase and hydrolase with the same scaffold.Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis.Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis.Crystal structure of IspF from Bacillus subtilis and absence of protein complex assembly among IspD/IspE/IspF enzymes in the MEP pathway.Investigation of structural mimetics of natural phosphate ion binding motifs.Design of novel ligands of CDP-methylerythritol kinase by mimicking direct protein-protein and solvent-mediated interactions.The MEP pathway and the development of inhibitors as potential anti-infective agents

P2860

Q27644293-471EDE28-5A50-4FCB-BF12-94AA2CF3D098 Q27644607-36AAC8DE-5394-473D-9504-D505BF54D85F Q27650391-D887D8FD-BD0F-4D6B-A40A-64513560DD37 Q27655698-6EBC2F32-BAED-4D31-9B46-F6722863A69B Q27660138-1D845636-ABF4-46DC-9FE3-E0972E9621AC Q27681397-B7FCD38F-FFCD-4ACB-A8A7-7C4575389DAC Q28483059-A899872F-28B3-4EF5-B5AF-99FC75DEBDC3 Q28727252-DC2D2897-8D41-4293-AF31-4AADECBF2D80 Q33610129-2804A709-421B-47CF-9CB5-B706EF966806 Q33773620-DF2C5642-7165-4E59-8FAF-B61BD125D6BC Q33846938-F4A62197-02CD-4ECB-9C55-21EB4D94D612 Q34014282-7B599393-6261-4821-B32D-3F38DCDD0D71 Q34017964-C9D2CCA2-B10F-4E7D-9257-47521F68673F Q34054239-4520E846-680C-4007-8661-9591F8921898 Q34353900-6BC274DB-F2D5-4C12-9B32-8794F5DDC2A8 Q35131319-F46D0472-3192-4FA3-9C3A-A474041CEF5D Q35710557-3C2FED8B-BE82-4115-970C-49AB70B7FF54 Q36066272-E22EDEEA-8AF4-4868-8C3A-9A3BFEEBF05B Q36290659-959A954B-B017-4FCA-8811-6497CFC275D6 Q36561313-CCB36107-72C3-4D3A-B732-84E5205C8994 Q36609497-C2AF0AC2-D580-41DB-B11E-5493159235D9 Q36795133-06619ED2-D04E-4F8A-9593-2029DDF84191 Q37107614-91CCF185-139C-4599-8438-03A2001F18D1 Q37503777-17E2068B-0D69-49E5-9B86-031939C8EAD4 Q37899789-247F9ADC-0C54-4D67-93F8-0332B179C8B6 Q38335784-23A18773-8002-4F28-8784-6F1F671383DD Q38389009-419F506B-BEFE-4841-B582-0AC07A6C3587 Q39969801-AE900D9D-6A0E-435C-9478-6CA5CF715BD3 Q42046315-5FF60BE1-6C15-45C7-AF08-C19659ECB861 Q42101450-5AFB3E08-D6C2-4809-8B2E-F5803004ED69 Q42396675-4405767C-1681-45E2-8B84-DB4EA1666B8D Q42691220-C0E23099-3249-4D8E-8CBC-40993DFF5DC3 Q43534464-96F325BE-CC50-4480-BB4A-9E4ABD9EA8DD Q45091600-AB19CA34-65EC-4295-9310-2FFE594A7A21 Q50043356-265A0317-7DB3-4C17-A3FA-6F2D3F0A2726 Q54289772-CA28F925-EF90-41FA-92E2-477C85675D8F Q54688012-65C7B4EE-56C5-447C-ACAD-41A5582224CB Q56994497-132AD63E-9F71-446F-A369-15D354F55B02

P2860

Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase

http://www.wikidata.org/entity/Q27641732

description

2003 nî lūn-bûn

@nan

2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Biosynthesis of isoprenoids: C ...... -2C-methyl-D-erythritol kinase

@ast

Biosynthesis of isoprenoids: C ...... -2C-methyl-D-erythritol kinase

@en

Biosynthesis of isoprenoids: C ...... -2C-methyl-D-erythritol kinase

@nl

type

label

Biosynthesis of isoprenoids: C ...... -2C-methyl-D-erythritol kinase

@ast

Biosynthesis of isoprenoids: C ...... -2C-methyl-D-erythritol kinase

@en

Biosynthesis of isoprenoids: C ...... -2C-methyl-D-erythritol kinase

@nl

prefLabel

Biosynthesis of isoprenoids: C ...... -2C-methyl-D-erythritol kinase

@ast

Biosynthesis of isoprenoids: C ...... -2C-methyl-D-erythritol kinase

@en

Biosynthesis of isoprenoids: C ...... -2C-methyl-D-erythritol kinase

@nl

P1433

Q27641732-48600E45-327C-45F5-879B-BAA5B4F10177

P1476

Q27641732-97182162-6B34-46B2-B9D6-5B477DFB2DFE

P2093

Q27641732-14CA50DE-78AA-47CB-B098-D08784FC7958

Q27641732-3429BCD4-5E07-4282-92FE-4D2B166FB2AF

Q27641732-3A8F4807-7038-4B0C-BE08-4398A450DE84

Q27641732-692A8170-47A1-44AD-A59D-2706C77D36A9

Q27641732-746ABD84-D479-4535-BA3A-05B27A6D2ADA

Q27641732-9AE68927-C63F-4F0F-8B38-FEFA4CB13C03

Q27641732-F35E6CD9-A749-4D54-A4C6-183D09D2BC2C

P2860

Q27641732-005668F1-7EAE-479B-93E6-BE8F106D30DB

Q27641732-02412771-03F0-4024-8793-F174CC4F6210

Q27641732-097EAC0D-773C-4946-901C-1796687524CF

Q27641732-0D30E45B-526E-460D-AE2D-18EB88334FB4

Q27641732-195C2644-59D6-45C8-8A5F-B55D1F6FC5A5

Q27641732-1B15A398-B95D-407D-A9BE-62C35898CDBA

Q27641732-22C14E00-1039-4ECA-AA1F-FD260F2D8450

Q27641732-24142AE7-EFC5-4D29-88C2-7124BADFC6A4

Q27641732-27E19220-A646-42C7-A0E4-108FFAE52044

Q27641732-2931873D-1285-40E4-9CFA-7C0B0AD0A389

P304

Q27641732-F47D7BE2-823B-444A-AF05-16745C255820

P31

Q27641732-41F39F78-895C-46CC-AAD4-5C5CC4C0092D

P356

Q27641732-DB928E63-7FB6-4BC5-81DA-2EE5C65F8A27

P407

Q27641732-D4B55066-56C5-449A-968C-51234AB43254

P433

Q27641732-F8CEEEAF-3846-4566-80F2-011DDF022C11

P478

Q27641732-040C3DFA-7C7A-4E7A-A2E4-5A5611CF72EB

P50

Q27641732-B136AF5B-261D-418C-A1D0-FD923416D6F6

Q27641732-B7B9C4E5-66B5-4170-8443-03827DAE30CB

Q27641732-E488BED6-B629-4BF8-B28C-90B747554035

P577

Q27641732-47E0355D-F2ED-4A80-9068-B9446BD4CB5F

P5875

Q27641732-5F286A6A-DBFE-4B00-911C-F1A56A15AFBC

P698

Q27641732-81B642DC-AC4F-4003-A97F-70D860D74D60

P921

Q27641732-BC85D017-A3CE-460D-9C85-AB137F537F23

P932

Q27641732-8DDC22B7-BB50-4C06-AB80-57701597094C

P356

PNAS.1533425100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Biosynthesis of isoprenoids: C ...... -2C-methyl-D-erythritol kinase

@en

P2093

Gordon A Leonard

http://www.w3.org/2001/XMLSchema#string

Lauris E Kemp

http://www.w3.org/2001/XMLSchema#string

Linda Miallau

http://www.w3.org/2001/XMLSchema#string

Magnus S Alphey

http://www.w3.org/2001/XMLSchema#string

Sean M McSweeney

http://www.w3.org/2001/XMLSchema#string

Stefan Hecht

http://www.w3.org/2001/XMLSchema#string

William N Hunter

http://www.w3.org/2001/XMLSchema#string

P2860

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein

Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

PROMOTIF--a program to identify and analyze structural motifs in proteins

A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis

Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol

Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases

Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate

Improved methods for building protein models in electron density maps and the location of errors in these models

P304

9173-8

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1533425100

http://www.w3.org/2001/XMLSchema#string

P407

P433

16

http://www.w3.org/2001/XMLSchema#string

P478

100

http://www.w3.org/2001/XMLSchema#string

P50

Adelbert Bacher

Wolfgang Eisenreich

P577

2003-08-05T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

10646188

http://www.w3.org/2001/XMLSchema#string

P698

12878729

http://www.w3.org/2001/XMLSchema#string

P921

crystal structure

P932

170891

http://www.w3.org/2001/XMLSchema#string