Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases - Wikidata - awgldk - TriplyDB

Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

http://www.wikidata.org/entity/Q27639568

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Molecular mechanisms of chemopreventive phytochemicals against gastroenterological cancer development Epigenetics and airways disease Epigenetic therapy in gastrointestinal cancer: the right combination Physiological and pathological implications of 5-hydroxymethylcytosine in diseases Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: disease and treatments Active DNA demethylation of the vertebrate genomes by DNA methyltransferases: deaminase, dehydroxymethylase or demethylase?Epigenetics of Renal Development and Disease Transgenerational stress memory is not a general response in Arabidopsis Cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic States in Arabidopsis Epigenetics in human disease and prospects for epigenetic therapy Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment.Meristem-specific expression of epigenetic regulators safeguards transposon silencing in Arabidopsis Use of Drosophila deoxynucleoside kinase to study mechanism of toxicity and mutagenicity of deoxycytidine analogs in Escherichia coli Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth.Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors.Determination of hypersensitivity to genotoxic agents among Escherichia coli single gene knockout mutants Impact of base analogues within a CpG dinucleotide on the binding of DNA by the methyl-binding domain of MeCP2 and methylation by DNMT1 ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth Augmenting antitumor immune responses with epigenetic modifying agents.Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells Epigenomics and ovarian carcinoma.Demethylation of DNA by decitabine in cancer chemotherapy.Genistein increases estrogen receptor beta expression in prostate cancer via reducing its promoter methylation.Rapid turnover of DNA methylation in human cells.Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity Dnmts and Tet target memory-associated genes after appetitive olfactory training in honey bees Zebularine: a unique molecule for an epigenetically based strategy in cancer chemotherapy. The magic of its chemistry and biology.2'-Deoxyriboguanylurea, the primary breakdown product of 5-aza-2'-deoxyribocytidine, is a mutagen, an epimutagen, an inhibitor of DNA methyltransferases and an inducer of 5-azacytidine-type fragile sites.In silico design of the first DNA-independent mechanism-based inhibitor of mammalian DNA methyltransferase Dnmt1.Reactivation of the silenced thyroid hormone receptor β gene expression delays thyroid tumor progression Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.DNA methylation regulates neuronal glutamatergic synaptic scaling.Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines Epigenetic drugs as pleiotropic agents in cancer treatment: biomolecular aspects and clinical applications.DNA cytosine methylation: structural and thermodynamic characterization of the epigenetic marking mechanism.Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma Activation of p16 gene silenced by DNA methylation in cancer cells by phosphoramidate derivatives of 2'-deoxyzebularine

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Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

http://www.wikidata.org/entity/Q27639568

description

2002 nî lūn-bûn

@nan

2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի օգոստոսին հրատարակված գիտական հոդված

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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name

Zebularine: A Novel DNA Methyl ...... ex with DNA Methyltransferases

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Zebularine: A Novel DNA Methyl ...... ex with DNA Methyltransferases

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Zebularine: A Novel DNA Methyl ...... ex with DNA Methyltransferases

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type

label

Zebularine: A Novel DNA Methyl ...... ex with DNA Methyltransferases

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Zebularine: A Novel DNA Methyl ...... ex with DNA Methyltransferases

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Zebularine: A Novel DNA Methyl ...... ex with DNA Methyltransferases

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prefLabel

Zebularine: A Novel DNA Methyl ...... ex with DNA Methyltransferases

@ast

Zebularine: A Novel DNA Methyl ...... ex with DNA Methyltransferases

@en

Zebularine: A Novel DNA Methyl ...... ex with DNA Methyltransferases

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Journal of Molecular Biology

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Zebularine: a novel DNA methyl ...... ex with DNA methyltransferases

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B A Connolly

http://www.w3.org/2001/XMLSchema#string

D P Hornby

http://www.w3.org/2001/XMLSchema#string

L Zhou

http://www.w3.org/2001/XMLSchema#string

X Cheng

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Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA

HhaI methyltransferase flips its target base out of the DNA helix

Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes

DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase

Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine

The DNA methyltransferases of mammals

The role of DNA methylation in mammalian epigenetics

Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex.

AdoMet-dependent methylation, DNA methyltransferases and base flipping.

DNA methylation, chromatin inheritance, and cancer.

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591-599

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DNA methylation

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2713825

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