NMR spatial structure of alpha-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors
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Solution conformation of alpha-conotoxin EI, a neuromuscular toxin specific for the alpha 1/delta subunit interface of torpedo nicotinic acetylcholine receptorA new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activitySolution conformation of alphaA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineusProtein Folding Determinants: Structural Features Determining Alternative Disulfide Pairing in α- and χ/λ-Conotoxins † , ‡α-RgIA, a Novel Conotoxin That Blocks the α9α10 nAChR: Structure and Identification of Key Receptor-Binding ResiduesDithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptidesStructures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformationsBlockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculationsStructural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.Photoactivatable alpha-conotoxins reveal contacts with all subunits as well as antagonist-induced rearrangements in the Torpedo californica acetylcholine receptor.Candoxin, a novel toxin from Bungarus candidus, is a reversible antagonist of muscle (alphabetagammadelta ) but a poorly reversible antagonist of neuronal alpha 7 nicotinic acetylcholine receptors.Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.Snake venom alpha-neurotoxins and other 'three-finger' proteins.Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor.Snake and snail toxins acting on nicotinic acetylcholine receptors: fundamental aspects and medical applications.Structure-activity relationships of alpha-conotoxins targeting neuronal nicotinic acetylcholine receptors.Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails.Sizing the protein translocation pathway of colicin Ia channels.Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads.Fluorinated amino acids: compatibility with native protein structures and effects on protein-protein interactions.Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors.Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives.Acetylcholine promotes binding of α-conotoxin MII at α3 β2 nicotinic acetylcholine receptors."Weak toxin" from Naja kaouthia is a nontoxic antagonist of alpha 7 and muscle-type nicotinic acetylcholine receptors.Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists.Epimerization-free access to C-terminal cysteine peptide acids, carboxamides, secondary amides, and esters via complimentary strategies.
P2860
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P2860
NMR spatial structure of alpha-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
NMR spatial structure of alpha ...... otinic acetylcholine receptors
@ast
NMR spatial structure of alpha ...... otinic acetylcholine receptors
@en
NMR spatial structure of alpha ...... otinic acetylcholine receptors
@nl
type
label
NMR spatial structure of alpha ...... otinic acetylcholine receptors
@ast
NMR spatial structure of alpha ...... otinic acetylcholine receptors
@en
NMR spatial structure of alpha ...... otinic acetylcholine receptors
@nl
prefLabel
NMR spatial structure of alpha ...... otinic acetylcholine receptors
@ast
NMR spatial structure of alpha ...... otinic acetylcholine receptors
@en
NMR spatial structure of alpha ...... otinic acetylcholine receptors
@nl
P2093
P2860
P1433
P1476
NMR spatial structure of alpha ...... otinic acetylcholine receptors
@en
P2093
A S Arseniev
C Methfessel
I V Maslennikov
V I Tsetlin
V T Ivanov
Z O Shenkarev
P2860
P304
P356
10.1016/S0014-5793(99)00069-1
P407
P577
1999-02-12T00:00:00Z