Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations - Wikidata - awgldk - TriplyDB

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

http://www.wikidata.org/entity/Q28274662

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A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease Nicotine binding to brain receptors requires a strong cation-pi interaction Mammalian nicotinic acetylcholine receptors: from structure to function Size matters in activation/inhibition of ligand-gated ion channels Inside-out neuropharmacology of nicotinic drugs Glycine receptor mechanism elucidated by electron cryo-microscopy.Protein Folding Determinants: Structural Features Determining Alternative Disulfide Pairing in α- and χ/λ-Conotoxins † , ‡Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics Crystal structure of a human GABAA receptor Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-α-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity α-RgIA, a Novel Conotoxin That Blocks the α9α10 nAChR: Structure and Identification of Key Receptor-Binding Residues Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism Conformational Remodeling of Femtomolar Inhibitor−Acetylcholinesterase Complexes in the Crystalline State Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding Protein Principles of activation and permeation in an anion-selective Cys-loop receptor Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC Acetylcholine-Binding Protein in the Hemolymph of the Planorbid Snail Biomphalaria glabrata Is a Pentagonal Dodecahedron (60 Subunits)Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHβE Suggests a Unique Mode of Antagonism Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist Creating an 7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein: CRYSTALLOGRAPHIC AND LIGAND SELECTIVITY ANALYSES Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine 4 2 Receptors: UNIQUE ROLE OF HALOGEN BONDING REVEALED NMR structures of the transmembrane domains of the α4β2 nAChR Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein Structural Characterization of Binding Mode of Smoking Cessation Drugs to Nicotinic Acetylcholine Receptors through Study of Ligand Complexes with Acetylcholine-binding Protein Molecular actions of smoking cessation drugs at 4 2 nicotinic receptors defined in crystal structures of a homologous binding protein Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

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Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

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2005 nî lūn-bûn

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2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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Structures of Aplysia AChBP co ...... g interfaces and conformations

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Structures of Aplysia AChBP co ...... g interfaces and conformations

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Gerlind Sulzenbacher

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Palmer Taylor

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Scott B Hansen

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Yves Bourne

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P2860

PROCHECK: a program to check the stereochemical quality of protein structures

NMR solution structure of alpha-conotoxin ImI and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

NMR spatial structure of alpha-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors

Automated protein model building combined with iterative structure refinement

Refinement of macromolecular structures by the maximum-likelihood method

The CCP4 suite: programs for protein crystallography

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

Relations between structure and nicotine-like activity: X-ray crystal structure analysis of (-)-cytisine and (-)-lobeline hydrochloride and a comparison with (-)-nicotine and other nicotine-like compounds

Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line

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20

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Pascale Marchot

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7571935

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