Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase
about
Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysisMisfolded CuZnSOD and amyotrophic lateral sclerosisALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomesPathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.Structural Characterization of Zinc-deficient Human Superoxide Dismutase and Implications for ALSSuperoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosisStructural and dynamic aspects related to oligomerization of apo SOD1 and its mutantsPurification and crystallization of human Cu/Zn superoxide dismutase recombinantly produced in the protozoanLeishmania tarentolaeStructural switching of Cu,Zn-superoxide dismutases at loop VI: insights from the crystal structure of 2-mercaptoethanol-modified enzymeMutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.Local unfolding in a destabilized, pathogenic variant of superoxide dismutase 1 observed with H/D exchange and mass spectrometry.Cis-suppression to arrest protein aggregation in mammalian cells.Impact of genetic variation on three dimensional structure and function of proteins.Cu,Zn-superoxide dismutase increases toxicity of mutant and zinc-deficient superoxide dismutase by enhancing protein stability.Altered thiol chemistry in human amyotrophic lateral sclerosis-linked mutants of superoxide dismutase 1Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypesThe structural biochemistry of the superoxide dismutases.Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro.Protein aggregation in motor neurone disorders.Molecular characterization of two superoxide dismutases from Hydra vulgaris.Rapid profiling of disease alleles using a tunable reporter of protein misfolding.A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop.A possible therapeutic target for Lou Gehrig's disease.Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis.Cellular Redox Systems Impact the Aggregation of Cu,Zn Superoxide Dismutase Linked to Familial Amyotrophic Lateral Sclerosis.Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis.Different immunoreactivity against monoclonal antibodies between wild-type and mutant copper/zinc superoxide dismutase linked to amyotrophic lateral sclerosis.Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.Molecular dynamics of a far positioned SOD1 mutant V14M reveals pathogenic misfolding behavior.A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants
P2860
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P2860
Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Insights into Lou Gehrig's dis ...... man Cu,Zn superoxide dismutase
@ast
Insights into Lou Gehrig's dis ...... man Cu,Zn superoxide dismutase
@en
Insights into Lou Gehrig's dis ...... man Cu,Zn superoxide dismutase
@nl
type
label
Insights into Lou Gehrig's dis ...... man Cu,Zn superoxide dismutase
@ast
Insights into Lou Gehrig's dis ...... man Cu,Zn superoxide dismutase
@en
Insights into Lou Gehrig's dis ...... man Cu,Zn superoxide dismutase
@nl
prefLabel
Insights into Lou Gehrig's dis ...... man Cu,Zn superoxide dismutase
@ast
Insights into Lou Gehrig's dis ...... man Cu,Zn superoxide dismutase
@en
Insights into Lou Gehrig's dis ...... man Cu,Zn superoxide dismutase
@nl
P2093
P1476
Insights into Lou Gehrig's dis ...... man Cu,Zn superoxide dismutase
@en
P2093
Cami K Bruns
Elizabeth D Getzoff
John A Tainer
Maria M Thayer
Michael DiDonato
Rosa M F Cardoso
Terence P Lo
P304
P356
10.1016/S0022-2836(02)01090-2
P407
P577
2002-11-22T00:00:00Z