Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.
about
Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosisPrion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?The complex molecular biology of amyotrophic lateral sclerosis (ALS)Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis.Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival.Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methodsProtease-resistant SOD1 aggregates in amyotrophic lateral sclerosis demonstrated by paraffin-embedded tissue (PET) blot.Proteomic analysis reveals differentially regulated protein acetylation in human amyotrophic lateral sclerosis spinal cord.Molecular dissection of ALS-associated toxicity of SOD1 in transgenic mice using an exon-fusion approach.Enthalpic barriers dominate the folding and unfolding of the human Cu, Zn superoxide dismutase monomerWild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse.Evidence for prion-like mechanisms in several neurodegenerative diseases: potential implications for immunotherapyConformational changes in redox pairs of protein structures.A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop.Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosisTorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS.Analysis of SOD1 mutations in a Chinese population with amyotrophic lateral sclerosis: a case-control study and literature review.Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis.Cellular Redox Systems Impact the Aggregation of Cu,Zn Superoxide Dismutase Linked to Familial Amyotrophic Lateral Sclerosis.SOD1 mutations targeting surface hydrogen bonds promote amyotrophic lateral sclerosis without reducing apo-state stability.Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models.Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1G93A Rodent Spinal Cord Tissue.A chemical chaperone-based drug candidate is effective in a mouse model of amyotrophic lateral sclerosis (ALS).A novel T137A SOD1 mutation in an Italian family with two subjects affected by amyotrophic lateral sclerosisAggregated SOD1 causes selective death of cultured human motor neurons
P2860
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P2860
Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.
@ast
Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.
@en
type
label
Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.
@ast
Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.
@en
prefLabel
Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.
@ast
Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.
@en
P2860
P356
P1476
Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.
@en
P2093
Lawrence J Hayward
P2860
P304
P356
10.1159/000089616
P577
2005-01-01T00:00:00Z