Catalytic mechanism of Escherichia coli isopentenyl diphosphate isomerase involves Cys-67, Glu-116, and Tyr-104 as suggested by crystal structures of complexes with transition state analogues and irreversible inhibitors
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Determination of Kinetics and the Crystal Structure of a Novel Type 2 Isopentenyl Diphosphate: Dimethylallyl Diphosphate Isomerase fromStreptococcus pneumoniaeMonoclinic form of isopentenyl diphosphate isomerase: a case of polymorphism in biomolecular crystalsCrystal Structure of Type 2 Isopentenyl Diphosphate Isomerase from Thermus thermophilus in Complex with Inorganic Pyrophosphate †Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitorsChemistry of the retinoid (visual) cycleIsoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasitesIdentification of an Archaeal type II isopentenyl diphosphate isomerase in methanothermobacter thermautotrophicusType II isopentenyl diphosphate isomerase: probing the mechanism with alkyne/allene diphosphate substrate analoguesAn enzymatic platform for the synthesis of isoprenoid precursors.Overexpression of an isopentenyl diphosphate isomerase gene to enhance trans-polyisoprene production in Eucommia ulmoides Oliver.Identification of a fourth family of lycopene cyclases in photosynthetic bacteria.Kinetic and spectroscopic characterization of type II isopentenyl diphosphate isomerase from Thermus thermophilus: evidence for formation of substrate-induced flavin speciesControl of carotenoid biosynthesis through a heme-based cis-trans isomerase.Isopentenyl diphosphate isomerase catalyzed reactions in D2O: product release limits the rate of this sluggish enzyme-catalyzed reaction.Stereochemical studies of the type II isopentenyl diphosphate-dimethylallyl diphosphate isomerase implicate the FMN coenzyme in substrate protonation.Noncanonical reactions of flavoenzymes.The non-mevalonate pathway of isoprenoid precursor biosynthesis.The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.Inhibition Studies on Enzymes Involved in Isoprenoid Biosynthesis: Focus on Two Potential Drug Targets: DXR and IDI-2 Enzymes.Mechanistic aspects of carotenoid biosynthesis.Cloning and functional characterization of an isopentenyl diphosphate isomerase gene from Tripterygium wilfordii.The type II isopentenyl Diphosphate:Dimethylallyl diphosphate isomerase (IDI-2): A model for acid/base chemistry in flavoenzyme catalysis.Type-2 isopentenyl diphosphate isomerase: evidence for a stepwise mechanism.Type II isopentenyl diphosphate isomerase from Synechocystis sp. strain PCC 6803.Isopentenyl diphosphate isomerase. Mechanism-based inhibition by diene analogues of isopentenyl diphosphate and dimethylallyl diphosphate.Linear free energy relationships demonstrate a catalytic role for the flavin mononucleotide coenzyme of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomeraseFunctional analysis of type 1 isopentenyl diphosphate isomerase from Halobacterium sp. NRC-1.A novel plant enzyme with dual activity: an atypical Nudix hydrolase and a dipeptidyl peptidase III.
P2860
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P2860
Catalytic mechanism of Escherichia coli isopentenyl diphosphate isomerase involves Cys-67, Glu-116, and Tyr-104 as suggested by crystal structures of complexes with transition state analogues and irreversible inhibitors
description
2003 nî lūn-bûn
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2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
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2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Catalytic mechanism of Escheri ...... es and irreversible inhibitors
@ast
Catalytic mechanism of Escheri ...... es and irreversible inhibitors
@en
Catalytic mechanism of Escheri ...... es and irreversible inhibitors
@nl
type
label
Catalytic mechanism of Escheri ...... es and irreversible inhibitors
@ast
Catalytic mechanism of Escheri ...... es and irreversible inhibitors
@en
Catalytic mechanism of Escheri ...... es and irreversible inhibitors
@nl
prefLabel
Catalytic mechanism of Escheri ...... es and irreversible inhibitors
@ast
Catalytic mechanism of Escheri ...... es and irreversible inhibitors
@en
Catalytic mechanism of Escheri ...... es and irreversible inhibitors
@nl
P2093
P2860
P356
P1476
Catalytic mechanism of Escheri ...... es and irreversible inhibitors
@en
P2093
C Dale Poulter
L Droogmans
Sam J Barkley
P2860
P304
11903-11908
P356
10.1074/JBC.M212823200
P407
P577
2003-01-22T00:00:00Z