CDR3 loop flexibility contributes to the degeneracy of TCR recognition
about
Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotypeQuantitative challenges in understanding ligand discrimination by alphabeta T cellsEvolving models of the immunopathogenesis of T cell-mediated drug allergy: The role of host, pathogens, and drug response.Adoptive T-cell therapy for LeukemiaBeyond model antigens: high-dimensional methods for the analysis of antigen-specific T cellsSurface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivityA T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I moleculeHow much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?Structures of MART-126/27–35 Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell RecognitionSingle MHC Mutation Eliminates Enthalpy Associated with T Cell Receptor BindingA New Twist in TCR Diversity Revealed by a Forbidden αβ TCRCrossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC MoleculesDistinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientationDifferent Thermodynamic Binding Mechanisms and Peptide Fine Specificities Associated with a Panel of Structurally Similar High-Affinity T Cell Receptors † ‡Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificityT Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular FlexibilityHard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptabilityStructural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c-I-EA Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR ConformersDisparate Degrees of Hypervariable Loop Flexibility Control T-Cell Receptor Cross-Reactivity, Specificity, and Binding MechanismT Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility ComplexCrossreactivity of a human autoimmune TCR is dominated by a single TCR loopEffect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand SpecificityDeconstructing the Peptide-MHC Specificity of T Cell RecognitionHigh-Throughput Sequencing-Based Immune Repertoire Study during Infectious DiseaseWhat Is Direct Allorecognition?The CD8 T-cell response during tolerance induction in liver transplantationThe molecular basis of TCR germline bias for MHC is surprisingly simpleStructural basis of affinity maturation and intramolecular cooperativity in a protein-protein interactionStructure of a TCR-Mimic Antibody with Target Predicts Pharmacogenetics.DynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles.Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.The effect of mutations on the alloreactive T cell receptor/peptide-MHC interface structure: a molecular dynamics study.Estimating the diversity, completeness, and cross-reactivity of the T cell repertoire.Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.TCRep 3D: an automated in silico approach to study the structural properties of TCR repertoires.Evolving concepts of specificity in immune reactionsVgamma2Vdelta2 T Cell Receptor recognition of prenyl pyrophosphates is dependent on all CDRsT cell receptor recognition of self and foreign antigens in the induction of autoimmunity.T cell receptor-ligand interactions: a conformational preequilibrium or an induced fit.
P2860
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P2860
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
@ast
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
@en
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
@nl
type
label
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
@ast
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
@en
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
@nl
prefLabel
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
@ast
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
@en
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
@nl
P2093
P3181
P356
P1433
P1476
CDR3 loop flexibility contributes to the degeneracy of TCR recognition
@en
P2093
Alice Kearney
Claude Grégoire
Claudine Darnault
Dominique Housset
Gilbert Mazza
Jean-Baptiste Reiser
Juan Carlos Fontecilla-Camps
Thomas Mosser
P3181
P356
10.1038/NI891
P407
P577
2003-03-01T00:00:00Z