Quantitative challenges in understanding ligand discrimination by alphabeta T cells
about
Ultrasensitivity in multisite phosphorylation of membrane-anchored proteinsNetwork, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune systemTCR Signal Strength Alters T-DC Activation and Interaction Times and Directs the Outcome of DifferentiationExperimental and theoretical bases for mechanisms of antigen discrimination by T cellsT cell responses to antigen: hasty proposals resolved through long engagementsDesert ants achieve reliable recruitment across noisy interactionsA role for rebinding in rapid and reliable T cell responses to antigenAttenuated T cell responses to a high-potency ligand in vivo.Perspectives for computer modeling in the study of T cell activationComputational analysis of T cell receptor signaling and ligand discrimination--past, present, and future.Chemodetection in fluctuating environments: receptor coupling, buffering, and antagonism.Use of TIRF to Monitor T-Lymphocyte Membrane Dynamics with Submicrometer and Subsecond Resolution.T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar AntigensPhenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism.Spatial organization and signal transduction at intercellular junctionsAffinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.Altered peptide ligands can modify the Th2 T cell response to the immunodominant 161-175 peptide of LACK (Leishmania homolog for the receptor of activated C kinase).Variability and robustness in T cell activation from regulated heterogeneity in protein levelsTowards a liquid self: how time, geography, and life experiences reshape the biological identity.Lighting Up T Lymphocyte Signaling with Quantitative Phosphoproteomics.TCR/pMHC Interaction: Phenotypic Model for an Unsolved Enigma.A mathematical framework for analyzing T cell receptor scanning of peptides.Multiple steady states and the form of response functions to antigen in a model for the initiation of T-cell activation.Effects of thymic selection on T cell recognition of foreign and tumor antigenic peptides.Untangling the Hairball: Fitness-Based Asymptotic Reduction of Biological Networks.Principles of adaptive sorting revealed by in silico evolution.Physical Limit to Concentration Sensing Amid Spurious Ligands.Identifying feasible operating regimes for early T-cell recognition: The speed, energy, accuracy trade-off in kinetic proofreading and adaptive sorting
P2860
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P2860
Quantitative challenges in understanding ligand discrimination by alphabeta T cells
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Quantitative challenges in understanding ligand discrimination by alphabeta T cells
@ast
Quantitative challenges in understanding ligand discrimination by alphabeta T cells
@en
Quantitative challenges in understanding ligand discrimination by alphabeta T cells
@nl
type
label
Quantitative challenges in understanding ligand discrimination by alphabeta T cells
@ast
Quantitative challenges in understanding ligand discrimination by alphabeta T cells
@en
Quantitative challenges in understanding ligand discrimination by alphabeta T cells
@nl
prefLabel
Quantitative challenges in understanding ligand discrimination by alphabeta T cells
@ast
Quantitative challenges in understanding ligand discrimination by alphabeta T cells
@en
Quantitative challenges in understanding ligand discrimination by alphabeta T cells
@nl
P2860
P3181
P1433
P1476
Quantitative challenges in understanding ligand discrimination by alphabeta T cells
@en
P2093
Ofer Feinerman
Ronald N Germain
P2860
P304
P3181
P356
10.1016/J.MOLIMM.2007.03.028
P407
P577
2007-09-06T00:00:00Z