Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide
about
Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscodingTwo conformational states in the crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site.Geneticin Stabilizes the Open Conformation of the 5' Region of Hepatitis C Virus RNA and Inhibits Viral ReplicationRecent Advances in Developing Small Molecules Targeting Nucleic AcidIsostericity and tautomerism of base pairs in nucleic acidsAntibiotics that target protein synthesisAntiviral activity of geneticin against dengue virus.Breaking pseudo-twofold symmetry in the poliovirus 3'-UTR Y-stem by restoring Watson-Crick base pairsThe bacterial and mitochondrial ribosomal A-site molecular switches possess different conformational substatesA structural basis for the antibiotic resistance conferred by an A1408G mutation in 16S rRNA and for the antiprotozoal activity of aminoglycosidesIdentification of the molecular attributes required for aminoglycoside activity against LeishmaniaCrystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sitesThe bacterial ribosome as a target for antibioticsStructural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.Association of aminoglycosidic antibiotics with the ribosomal A-site studied with Brownian dynamicsDisaccharide mimetics of the aminoglycoside antibiotic neamine.Search for novel aminoglycosides by combining fragment-based virtual screening and 3D-QSAR scoringBinding of aminoglycoside antibiotics to helix 69 of 23S rRNAAnalysis of the contribution of individual substituents in 4,6-aminoglycoside-ribosome interactionThree-dimensional motifs from the SCOR, structural classification of RNA database: extruded strands, base triples, tetraloops and U-turnsPositional and neighboring base pair effects on the thermodynamic stability of RNA single mismatchesElectrostatic interactions in aminoglycoside-RNA complexes.RNA as a drug target: the case of aminoglycosides.Synthesis and conformational analysis of 6-C-methyl-substituted 2-acetamido-2-deoxy-beta-D-glucopyranosyl mono- and disaccharides.A mouse model for nonsense mutation bypass therapy shows a dramatic multiday response to geneticin.Antibiotics and the ribosome.Effects of tRNA modification on translational accuracy depend on intrinsic codon-anticodon strengthG418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis.Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons.Strategies for the design of RNA-binding small molecules.Use of 2-aminopurine as a fluorescent tool for characterizing antibiotic recognition of the bacterial rRNA A-site.Mechanism of action of a novel series of naphthyridine-type ribosome inhibitors: enhancement of tRNA footprinting at the decoding site of 16S rRNA.The molecular basis for A-site mutations conferring aminoglycoside resistance: relationship between ribosomal susceptibility and X-ray crystal structures.An In Silico Approach for Characterization of an Aminoglycoside Antibiotic-Resistant Methyltransferase Protein from Pyrococcus furiosus (DSM 3638)Glycosyltransferases: mechanisms and applications in natural product development.Detection and Quantification of Ribosome Inhibition by Aminoglycoside Antibiotics in Living Bacteria Using an Orthogonal Ribosome-Controlled Fluorescent ReporterEngineering Strategies to Decode and Enhance the Genomes of Coral Symbionts.The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6'-N-acetyltransferase and the role of 6'-NH2 in antibacterial activityCrystal structure and specific binding mode of sisomicin to the bacterial ribosomal decoding site.A minimum structure of aminoglycosides that causes an initiation shift of trans-translation
P2860
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P2860
Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide
description
2003 nî lūn-bûn
@nan
2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Crystal structure of geneticin ...... mal RNA A site oligonucleotide
@ast
Crystal structure of geneticin ...... mal RNA A site oligonucleotide
@en
Crystal structure of geneticin ...... mal RNA A site oligonucleotide
@nl
type
label
Crystal structure of geneticin ...... mal RNA A site oligonucleotide
@ast
Crystal structure of geneticin ...... mal RNA A site oligonucleotide
@en
Crystal structure of geneticin ...... mal RNA A site oligonucleotide
@nl
prefLabel
Crystal structure of geneticin ...... mal RNA A site oligonucleotide
@ast
Crystal structure of geneticin ...... mal RNA A site oligonucleotide
@en
Crystal structure of geneticin ...... mal RNA A site oligonucleotide
@nl
P3181
P1476
Crystal structure of geneticin ...... mal RNA A site oligonucleotide
@en
P2093
Quentin Vicens
P304
P3181
P356
10.1016/S0022-2836(02)01435-3
P407
P50
P577
2003-02-28T00:00:00Z