Structural basis for partial agonist action at ionotropic glutamate receptors
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Allosteric control of an ionotropic glutamate receptor with an optical switch.Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptorsThe glutamate storyFunctional insights from glutamate receptor ion channel structuresEmerging models of glutamate receptor ion channel structure and functionSize matters in activation/inhibition of ligand-gated ion channelsComputational study of synthetic agonist ligands of ionotropic glutamate receptorsPartial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acidIonotropic glutamate-like receptor 2 binds D-serine and glycineTARP auxiliary subunits switch AMPA receptor antagonists into partial agonists6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) Forms an Irreversible Bond To the Active Site of the GluR2 AMPA Receptor †Structure of the S1S2 glutamate binding domain of GLuR3Mechanisms of Antagonism of the GluR2 AMPA Receptor: Structure and Dynamics of the Complex of Two Willardiine Antagonists with the Glutamate Binding DomainFull Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-DideoxyneodysiherbaineEnhanced Efficacy without Further Cleft Closure: Reevaluating Twist as a Source of Agonist Efficacy in AMPA ReceptorsMolecular Mechanism of Flop Selectivity and Subsite Recognition for an AMPA Receptor Allosteric Modulator: Structures of GluA2 and GluA3 in Complexes with PEPABinding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonistsCrystal structure of the glutamate receptor GluA1 N-terminal domainMechanisms of Modal Activation of GluA3 ReceptorsStructural and Functional Analysis of Two New Positive Allosteric Modulators of GluA2 Desensitization and DeactivationMechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONSStructural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-D-Aspartate ReceptorsMolecular actions of smoking cessation drugs at 4 2 nicotinic receptors defined in crystal structures of a homologous binding proteinA Conformational Intermediate in Glutamate Receptor ActivationThermodynamics and Mechanism of the Interaction of Willardiine Partial Agonists with a Glutamate Receptor: Implications for Drug DevelopmentL-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domainModulation of non-NMDA receptor gating by auxiliary subunitsGlutamate receptor ion channels: structure, regulation, and functionInfluence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptorsConductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane regionAuxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor FunctionVariant ionotropic glutamate receptors as chemosensory receptors in DrosophilaA quantized mechanism for activation of pannexin channelsStructural mechanism of glutamate receptor activation and desensitization.AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins.Receptor occupancy and channel-opening kinetics: a study of GLUR1 L497Y AMPA receptor.Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium.A charge-inverting mutation in the "linker" region of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors alters agonist binding and gating kinetics independently of allosteric modulators.Glutamate receptors as seen by light: spectroscopic studies of structure-function relationships.
P2860
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P2860
Structural basis for partial agonist action at ionotropic glutamate receptors
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structural basis for partial agonist action at ionotropic glutamate receptors
@ast
Structural basis for partial agonist action at ionotropic glutamate receptors
@en
Structural basis for partial agonist action at ionotropic glutamate receptors
@nl
type
label
Structural basis for partial agonist action at ionotropic glutamate receptors
@ast
Structural basis for partial agonist action at ionotropic glutamate receptors
@en
Structural basis for partial agonist action at ionotropic glutamate receptors
@nl
prefLabel
Structural basis for partial agonist action at ionotropic glutamate receptors
@ast
Structural basis for partial agonist action at ionotropic glutamate receptors
@en
Structural basis for partial agonist action at ionotropic glutamate receptors
@nl
P2093
P3181
P356
P1433
P1476
Structural basis for partial agonist action at ionotropic glutamate receptors
@en
P2093
Eric Gouaux
Mark L Mayer
Stephen F Traynelis
P2888
P304
P3181
P356
10.1038/NN1091
P407
P577
2003-08-01T00:00:00Z
P5875
P6179
1007878973