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TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

http://www.wikidata.org/entity/Q27648934

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Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins AMPA receptors as a molecular target in epilepsy therapy Computational study of synthetic agonist ligands of ionotropic glutamate receptors 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) Forms an Irreversible Bond To the Active Site of the GluR2 AMPA Receptor †Structural Insights into the Extracytoplasmic Thiamine-Binding Lipoprotein p37 of Mycoplasma hyorhinis Mechanisms of Antagonism of the GluR2 AMPA Receptor: Structure and Dynamics of the Complex of Two Willardiine Antagonists with the Glutamate Binding Domain Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS The Structure of (-)-Kaitocephalin Bound to the Ligand Binding Domain of the (S)- -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)/Glutamate Receptor, GluA2 The Loss of an Electrostatic Contact Unique to AMPA Receptor Ligand Binding Domain 2 Slows Channel Activation Glutamate receptor ion channels: structure, regulation, and function Quantifying the effects of elastic collisions and non-covalent binding on glutamate receptor trafficking in the post-synaptic density Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function Cellular plasticity for group I mGluR-mediated epileptogenesis.AMPA receptor/TARP stoichiometry visualized by single-molecule subunit counting Selective excitatory actions of DNQX and CNQX in rat thalamic neurons.TARP γ-2 Is Required for Inflammation-Associated AMPA Receptor Plasticity within Lamina II of the Spinal Cord Dorsal Horn.Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3.Auxiliary subunits: shepherding AMPA receptors to the plasma membrane.Targeting α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors in epilepsy.Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation.Stargazin promotes closure of the AMPA receptor ligand-binding domain Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors.A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition.Stargazin (TARP gamma-2) is required for compartment-specific AMPA receptor trafficking and synaptic plasticity in cerebellar stellate cells.Critical role for TARPs in early development despite broad functional redundancy The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits.A single fear-inducing stimulus induces a transcription-dependent switch in synaptic AMPAR phenotype Transmembrane AMPAR regulatory protein γ-2 is required for the modulation of GABA release by presynaptic AMPARs.TARP redundancy is critical for maintaining AMPA receptor function.Probing TARP modulation of AMPA receptor conductance with polyamine toxins.Structure of an agonist-bound ionotropic glutamate receptor Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits.Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations.NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH.Topological Regulation of Synaptic AMPA Receptor Expression by the RNA-Binding Protein CPEB3.Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum C-terminal domains of transmembrane alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor regulatory proteins not only facilitate trafficking but are major modulators of AMPA receptor function

P2860

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P2860

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

http://www.wikidata.org/entity/Q27648934

description

2007 nî lūn-bûn

@nan

2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

@ast

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

@en

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

@nl

type

label

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

@ast

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

@en

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

@nl

prefLabel

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

@ast

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

@en

TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

@nl

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SCIENCE.1146317

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TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists

@en

P2093

Franklin A Hays

http://www.w3.org/2001/XMLSchema#string

Robert M Stroud

http://www.w3.org/2001/XMLSchema#string

Roger A Nicoll

http://www.w3.org/2001/XMLSchema#string

P2860

Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins

Genome-wide atlas of gene expression in the adult mouse brain

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes

Structural basis for partial agonist action at ionotropic glutamate receptors

Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII)

Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors

Competitive AMPA receptor antagonists.

Molecular targets versus models for new antiepileptic drug discovery

Auxiliary subunits assist AMPA-type glutamate receptors.

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815-817

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scholarly article

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10.1126/SCIENCE.1146317

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5851

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318

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2007-11-01T00:00:00Z

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5871466

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17975069

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