Crystal structure of extended-spectrum beta-lactamase Toho-1: insights into the molecular mechanism for catalytic reaction and substrate specificity expansion
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Three decades of beta-lactamase inhibitorsCrystal Structure of OXA-58 with the Substrate-Binding Cleft in a Closed State: Insights into the Mobility and Stability of the OXA-58 StructureFunctional and Structural Characterization of Four Glutaminases from Escherichia coli and Bacillus subtilis †Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-LactamaseMolecular docking and ligand specificity in fragment-based inhibitor discoveryImprovement of crystal quality by surface mutations of β-lactamase Toho-1The active site protonation states of perdeuterated Toho-1 β-lactamase determined by neutron diffraction support a role for Glu166 as the general base in acylationNeutron and X-ray Crystal Structures of a Perdeuterated Enzyme Inhibitor Complex Reveal the Catalytic Proton Network of the Toho-1 -Lactamase for the Acylation ReactionStructural insights into the broadened substrate profile of the extended-spectrum β-lactamase OXY-1-1 from Klebsiella oxytocaCrystal Structure of the Extended-Spectrum -Lactamase PER-2 and Insights into the Role of Specific Residues in the Interaction with -Lactams and -Lactamase InhibitorsCrystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and its Complex with Moxalactam and ImipenemCrystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibioticsSubstrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.Enumerating pathways of proton abstraction based on a spatial and electrostatic analysis of residues in the catalytic site.Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases.Prediction of the evolution of ceftazidime resistance in extended-spectrum beta-lactamase CTX-M-9.A measure of the broad substrate specificity of enzymes based on 'duplicate' catalytic residuesMolecular basis for the catalytic specificity of the CTX-M extended-spectrum β-lactamases.Cefotaximases (CTX-M-ases), an expanding family of extended-spectrum beta-lactamases.The continuing challenge of ESBLs.New beta-lactamases: a paradigm for the rapid response of bacterial evolution in the clinical setting.Role of a mutation at position 167 of CTX-M-19 in ceftazidime hydrolysis.Distant and new mutations in CTX-M-1 beta-lactamase affect cefotaxime hydrolysis.Noncovalent complexes of an inactive mutant of CTX-M-9 with the substrate piperacillin and the corresponding product.Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity.Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil.Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum beta-lactamase Toho-1.In Silico Analysis of Glutaminase from Different Species of Escherichia and Bacillus.Amino acid residues that contribute to substrate specificity of class A beta-lactamase SME-1.Molecular dynamics and molecular docking studies on E166A point mutant, R274N/R276N double mutant, and E166A/R274N/R276N triple mutant forms of class A β-lactamases.Crystallographic Snapshots of Class A β-Lactamase Catalysis Reveal Structural Changes That Facilitate β-Lactam Hydrolysis.An evolutionarily conserved allosteric site modulates beta-lactamase activity.
P2860
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P2860
Crystal structure of extended-spectrum beta-lactamase Toho-1: insights into the molecular mechanism for catalytic reaction and substrate specificity expansion
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Crystal structure of extended- ...... ubstrate specificity expansion
@ast
Crystal structure of extended- ...... ubstrate specificity expansion
@en
Crystal structure of extended- ...... ubstrate specificity expansion
@nl
type
label
Crystal structure of extended- ...... ubstrate specificity expansion
@ast
Crystal structure of extended- ...... ubstrate specificity expansion
@en
Crystal structure of extended- ...... ubstrate specificity expansion
@nl
prefLabel
Crystal structure of extended- ...... ubstrate specificity expansion
@ast
Crystal structure of extended- ...... ubstrate specificity expansion
@en
Crystal structure of extended- ...... ubstrate specificity expansion
@nl
P2093
P356
P1433
P1476
Crystal structure of extended- ...... ubstrate specificity expansion
@en
P2093
Akiko Shimizu Ibuka
Hiroshi Matsuzawa
Hiroshi Sakai
Keizo Yamaguchi
Masaji Ishiguro
Yoshikazu Ishii
P304
P356
10.1021/BI0342822
P407
P577
2003-09-16T00:00:00Z