Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.
about
Carbapenems: past, present, and futureKinetic and Crystallographic Studies of Extended-Spectrum GES-11, GES-12, and GES-14 -LactamasesDesign and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-LactamaseInsights into -Lactamases from Burkholderia Species, Two Phylogenetically Related yet Distinct Resistance DeterminantsCan Inhibitor-Resistant Substitutions in the Mycobacterium tuberculosis -Lactamase BlaC Lead to Clavulanate Resistance?: a Biochemical Rationale for the Use of -Lactam- -Lactamase Inhibitor CombinationsA structural, epidemiological & genetic overview of Klebsiella pneumoniae carbapenemases (KPCs)Exploring the role of a conserved class A residue in the Ω-Loop of KPC-2 β-lactamase: a mechanism for ceftazidime hydrolysisGenetic factors associated with elevated carbapenem resistance in KPC-producing Klebsiella pneumoniae.Multiplex real-time PCR assay for detection and classification of Klebsiella pneumoniae carbapenemase gene (bla KPC) variantsVariants of β-lactamase KPC-2 that are resistant to inhibition by avibactam.Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop.Understanding the molecular determinants of substrate and inhibitor specificities in the Carbapenemase KPC-2: exploring the roles of Arg220 and Glu276.Genetic and Biochemical Characterization of FRI-1, a Carbapenem-Hydrolyzing Class A β-Lactamase from Enterobacter cloacaeKPC-9, a novel carbapenemase from clinical specimens in IsraelDirect detection and genotyping of Klebsiella pneumoniae carbapenemases from urine by use of a new DNA microarray test.Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-β-lactamases.Acinetobacter baumannii rOmpA vaccine dose alters immune polarization and immunodominant epitopes.A Structure-Based Classification of Class A β-Lactamases, a Broadly Diverse Family of Enzymes.Characterization of VCC-1, a Novel Ambler Class A Carbapenemase from Vibrio cholerae Isolated from Imported Retail Shrimp Sold in Canada.In vitro selection of variants resistant to beta-lactams plus beta-lactamase inhibitors in CTX-M beta-lactamases: predicting the in vivo scenario?QM/MM simulations as an assay for carbapenemase activity in class A β-lactamases.N152G, -S, and -T substitutions in CMY-2 β-lactamase increase catalytic efficiency for cefoxitin and inactivation rates for tazobactam.Elucidating the role of Trp105 in the KPC-2 β-lactamase.Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance.Antibiotic resistance and substrate profiles of the class A carbapenemase KPC-6In vitro prediction of the evolution of GES-1 β-lactamase hydrolytic activity.Following drug uptake and reactions inside Escherichia coli cells by Raman microspectroscopy.Structure-based screening of inhibitors against KPC-2: designing potential drug candidates against multidrug-resistant bacteria.Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.Relebactam is a Potent Inhibitor of the KPC-2 β-Lactamase and Restores the Susceptibility of Imipenem Against KPC-Producing Enterobacteriaceae.
P2860
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P2860
Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Substrate selectivity and a no ...... 7 in the KPC-2 beta-lactamase.
@ast
Substrate selectivity and a no ...... 7 in the KPC-2 beta-lactamase.
@en
type
label
Substrate selectivity and a no ...... 7 in the KPC-2 beta-lactamase.
@ast
Substrate selectivity and a no ...... 7 in the KPC-2 beta-lactamase.
@en
prefLabel
Substrate selectivity and a no ...... 7 in the KPC-2 beta-lactamase.
@ast
Substrate selectivity and a no ...... 7 in the KPC-2 beta-lactamase.
@en
P2093
P2860
P50
P356
P1476
Substrate selectivity and a no ...... 7 in the KPC-2 beta-lactamase.
@en
P2093
Andrea Endimiani
Anne M Distler
John M Hornick
Kristine M Hujer
Magdalena Taracila
P2860
P304
P356
10.1128/AAC.00197-10
P407
P577
2010-04-26T00:00:00Z