Structural comparison suggests that thermolysin and related neutral proteases undergo hinge-bending motion during catalysis
about
The metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidasesMAP_CHANNELS: a computation tool to aid in the visualization and characterization of solvent channels in macromolecular crystals.ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysisCrystal Structure of the Protealysin Precursor: INSIGHTS INTO PROPEPTIDE FUNCTIONStructural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1Structure of Gentlyase, the neutral metalloprotease ofPaenibacillus polymyxaThe use of trimethylamineN-oxide as a primary precipitating agent and related methylamine osmolytes as cryoprotective agents for macromolecular crystallographyExperimental and computational active site mapping as a starting point to fragment-based lead discoveryWater makes the difference: rearrangement of water solvation layer triggers non-additivity of functional group contributions in protein-ligand bindingSynthesis of Aspartame by Thermolysin: An X-ray Structural StudyEngineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer’s DiseaseMethyl, ethyl, propyl, butyl: futile but not for water, as the correlation of structure and thermodynamic signature shows in a congeneric series of thermolysin inhibitorsFirst structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenasesComparison of the Internal Dynamics of Metalloproteases Provides New Insights on Their Function and Evolution.A new method for modeling large-scale rearrangements of protein domains.Molecular dynamics of individual alpha-helices of bacteriorhodopsin in dimyristol phosphatidylocholine. I. Structure and dynamics.Single-point amino acid substitutions at the 119th residue of thermolysin and their pressure-induced activation.Bacterial extracellular zinc-containing metalloproteasesCarboxylate binding modes in zinc proteins: a theoretical studyAllosteric inhibition of the neuropeptidase neurolysin.The closed structure of presequence protease PreP forms a unique 10,000 Angstroms3 chamber for proteolysis.Further molecular characterization of the cloned Legionella pneumophila zinc metalloprotease.The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications.The role of calcium ions in the stability and instability of a thermolysin-like protease.Actinobacterial enzyme inhibitors--a review.Role of intermolecular disulfide bonds of the organic solvent-stable PST-01 protease in its organic solvent stability.Movable lobes and flexible loops in proteins. Structural deformations that control biochemical activity.Evidence that Asn542 of neprilysin (EC 3.4.24.11) is involved in binding of the P2' residue of substrates and inhibitors.Structural analysis of zinc substitutions in the active site of thermolysin.Cavity scaling: automated refinement of cavity-aware motifs in protein function prediction.Analysis of zinc binding sites in protein crystal structures.Protein rigidity and thermophilic adaptation.The effect of changing the hydrophobic S1' subsite of thermolysin-like proteases on substrate specificity.Unexpected crucial role of residue 272 in substrate specificity of fibroblast collagenase.Protein hinge bending as seen in molecular dynamics simulations of native and M61 mutant T4 lysozymes.Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors.The impact of cryosolution thermal contraction on proteins and protein crystals: volumes, conformation and order
P2860
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P2860
Structural comparison suggests that thermolysin and related neutral proteases undergo hinge-bending motion during catalysis
description
1992 nî lūn-bûn
@nan
1992 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
name
Structural comparison suggests ...... ending motion during catalysis
@ast
Structural comparison suggests ...... ending motion during catalysis
@en
Structural comparison suggests ...... ending motion during catalysis
@nl
type
label
Structural comparison suggests ...... ending motion during catalysis
@ast
Structural comparison suggests ...... ending motion during catalysis
@en
Structural comparison suggests ...... ending motion during catalysis
@nl
prefLabel
Structural comparison suggests ...... ending motion during catalysis
@ast
Structural comparison suggests ...... ending motion during catalysis
@en
Structural comparison suggests ...... ending motion during catalysis
@nl
P2093
P356
P1433
P1476
Structural comparison suggests ...... ending motion during catalysis
@en
P2093
B W Matthews
D E Tronrud
D R Holland
J N Jansonius
K M Flaherty
P304
P356
10.1021/BI00161A008
P407
P577
1992-11-24T00:00:00Z