Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1 - Wikidata - awgldk - TriplyDB

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

http://www.wikidata.org/entity/Q27667473

about

Antigenic peptide trimming by ER aminopeptidases--insights from structural studies Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing Structural basis for multifunctional roles of mammalian aminopeptidase N Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1 A Novel Family of Soluble Minimal Scaffolds Provides Structural Insight into the Catalytic Domains of Integral Membrane Metallopeptidases Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses Structure-based elucidation of the regulatory mechanism for aminopeptidase activity Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.Pathways of antigen processing.Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis.Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2.Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.ERAP1 variants are associated with ankylosing spondylitis in East Asian population: a new Chinese case-control study and meta-analysis of published series.The role of insulin-regulated aminopeptidase in MHC class I antigen presentation.The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitope ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2 Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1 Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing.Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.Combined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligands Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum.Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review).Running the gauntlet: from peptide generation to antigen presentation by MHC class I.Endoplasmic reticulum aminopeptidase 1 and interleukin-23 receptor in ankylosing spondylitis.Positioning of aminopeptidase inhibitors in next generation cancer therapy.Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases.ERAP1 in the pathogenesis of ankylosing spondylitis.The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion.New insights toward the pathogenesis of ankylosing spondylitis; genetic variations and epigenetic modifications.Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen.Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines.Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 Peptidome through differential processing determined by multiple peptide residues.

P2860

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P2860

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

http://www.wikidata.org/entity/Q27667473

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Structural basis for antigenic ...... reticulum aminopeptidase ERAP1

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Structural basis for antigenic ...... reticulum aminopeptidase ERAP1

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Structural basis for antigenic ...... reticulum aminopeptidase ERAP1

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label

Structural basis for antigenic ...... reticulum aminopeptidase ERAP1

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Structural basis for antigenic ...... reticulum aminopeptidase ERAP1

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Structural basis for antigenic ...... reticulum aminopeptidase ERAP1

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Structural basis for antigenic ...... reticulum aminopeptidase ERAP1

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Structural basis for antigenic ...... reticulum aminopeptidase ERAP1

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Structural basis for antigenic ...... reticulum aminopeptidase ERAP1

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P1433

Nature Structural & Molecular Biology

P1476

Structural basis for antigenic ...... reticulum aminopeptidase ERAP1

@en

P2093

Alfred L Goldberg

http://www.w3.org/2001/XMLSchema#string

Christos Zikos

http://www.w3.org/2001/XMLSchema#string

Irini Evnouchidou

http://www.w3.org/2001/XMLSchema#string

Kenneth L Rock

http://www.w3.org/2001/XMLSchema#string

Lawrence J Stern

http://www.w3.org/2001/XMLSchema#string

Tina T Nguyen

http://www.w3.org/2001/XMLSchema#string

P2860

Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase

Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation

Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design

MEROPS: the peptidase database

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Processing of X-ray diffraction data collected in oscillation mode

Structural comparison suggests that thermolysin and related neutral proteases undergo hinge-bending motion during catalysis

P2888

P304

604-613

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scholarly article

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4147346

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P356

10.1038/NSMB.2021

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P433

5

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P478

18

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P50

Efstratios Stratikos

Shih-Chung Chang

P577

2011-04-10T00:00:00Z

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51037812

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1013559492

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P698

21478864

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P921

endoplasmic reticulum

structural biology

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3087843

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