Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A
about
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.Crystal Structures of the Helicobacter pylori MTAN Enzyme Reveal Specific Interactions between S -Adenosylhomocysteine and the 5′-Alkylthio Binding SubsiteCrystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5'-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage PathwayAssessment of methylthioadenosine/S-adenosylhomocysteine nucleosidases of Borrelia burgdorferi as targets for novel antimicrobials using a novel high-throughput methodContinuous Fluorescence Assays for Reactions Involving AdenineHeat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase.A synchrotron radiation study of the one-dimensional complex of sodium with (1S)-N-carboxylato-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol, a member of the 'immucillin' familyAsparagine synthetase chemotherapy.A mediator of Rho-dependent invasion moonlights as a methionine salvage enzymeExpression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimicsStructure and inhibition of a quorum sensing target from Streptococcus pneumoniaeSynthesis of 5'-methylthio coformycins: specific inhibitors for malarial adenosine deaminaseThe essential role of methylthioadenosine phosphorylase in prostate cancer.Conformational freedom in tight binding enzymatic transition-state analogues.Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers.A complex of methylthioadenosine/S-adenosylhomocysteine nucleosidase, transition state analogue, and nucleophilic water identified by mass spectrometry.Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5'-methylthioadenosine phosphorylase.Transition-state structure of human 5'-methylthioadenosine phosphorylase.Transition-state analysis of S. pneumoniae 5'-methylthioadenosine nucleosidaseTransition-state analysis of Trypanosoma cruzi uridine phosphorylase-catalyzed arsenolysis of uridine.Leishmania infantum 5'-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target.Methylthioadenosine Suppresses Salmonella Virulence
P2860
Q27654037-7F2B3E96-80B7-41AE-B3D5-A4EB49998799Q27675111-C5C299F5-0D4C-40A4-96F1-04E91CCCC939Q28554851-6F541EE0-5494-4F9F-A565-FC7EEDBC3184Q33431764-4B0EE7C8-2C3C-438B-BE02-2EEA1E49B551Q33698415-164E494A-72B0-453A-86F0-68ECF4F425DEQ33772568-089F5901-7FC2-45CD-8C1B-FA56C5199AC6Q33793265-BDD21B02-CFDD-47D1-BBF0-BCBA1603B7D0Q34535185-3E6C752D-5542-45DB-BA3C-DE351F75BE59Q34658861-A9E76D55-DCAE-441F-8D9F-538DBF42DA55Q34923845-6039B967-6E03-4FCD-9492-0D716D485271Q35569129-DFB30F08-A93B-4E12-83C0-D804911E8798Q36222921-549B0A2B-063E-4F5A-9CC5-D012E7665300Q36840500-4BC92477-D458-46A2-AF9C-7638CCE7B65FQ36848868-6F4E05BD-6E4F-43AE-9F67-86A3CB8B785DQ37046624-268FC210-5EF2-41B8-A3C4-0DDFE599DBA3Q37206494-119E7268-B3AF-4C24-AD00-5004777AAF45Q38474958-FF0ED348-DA89-49ED-B94F-4684F98618FFQ39309476-19CFABD1-47C6-43C1-A9FD-EA281018966CQ40124146-6FF4B5F8-B52D-4F39-81A4-306BAC1F5686Q40736183-0F34FA4B-D213-4090-B0B6-3548211A6DF6Q42004597-0B138061-8765-44A4-A7D3-352CF970D65FQ42039210-78A71963-BB5F-4D23-A401-31273B69EBAFQ42410823-554BD68C-E57F-4F3C-90B4-FE47F1B807A2Q42775657-E04716C0-0C8E-4E8A-8298-E3DBEEFF656DQ47139107-794C8540-8F8E-4C03-8F02-9A2BF8301B1BQ58721434-FDC92329-4009-41EE-92DA-91F73BA24172
P2860
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Picomolar transition state ana ...... structure with MT-immucillin-A
@ast
Picomolar transition state ana ...... structure with MT-immucillin-A
@en
Picomolar transition state ana ...... structure with MT-immucillin-A
@nl
type
label
Picomolar transition state ana ...... structure with MT-immucillin-A
@ast
Picomolar transition state ana ...... structure with MT-immucillin-A
@en
Picomolar transition state ana ...... structure with MT-immucillin-A
@nl
prefLabel
Picomolar transition state ana ...... structure with MT-immucillin-A
@ast
Picomolar transition state ana ...... structure with MT-immucillin-A
@en
Picomolar transition state ana ...... structure with MT-immucillin-A
@nl
P2093
P356
P1433
P1476
Picomolar transition state ana ...... structure with MT-immucillin-A
@en
P2093
Gary B Evans
Peter C Tyler
Richard H Furneaux
Vipender Singh
Wuxian Shi
P356
10.1021/BI0358420
P407
P577
2004-01-13T00:00:00Z