Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
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Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applicationsCoevolution of T-cell receptors with MHC and non-MHC ligandsStructure of a lamprey variable lymphocyte receptor in complex with a protein antigenA structural basis for antigen recognition by the T cell-like lymphocytes of sea lampreyAtypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural AnalysisProtein assembly mediated by sulfonatocalix[4]areneA second TCRδ locus in Galliformes uses antibody-like V domains: insight into the evolution of TCRδ and TCRμ genes in tetrapodsIsolation of anti-toxin single domain antibodies from a semi-synthetic spiny dogfish shark display library.Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points.Immunological applications of single-domain llama recombinant antibodies isolated from a naïve library.Anchored design of protein-protein interfaces.A case of convergence: why did a simple alternative to canonical antibodies arise in sharks and camels?Assessing combinatorial strategies to multimerize libraries of single-domain antibodies.Engineered antibody variable and constant domains as therapeutic candidates.The Shark Strikes Twice: Hypervariable Loop 2 of Shark IgNAR Antibody Variable Domains and Its Potential to Function as an Autonomous Paratope.Comparative transcriptomics of elasmobranchs and teleosts highlight important processes in adaptive immunity and regional endothermy.Natural and man-made V-gene repertoires for antibody discovery.Complex structure of type VI peptidoglycan muramidase effector and a cognate immunity protein.Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates.Biotechnological applications of recombinant single-domain antibody fragments.Role of human immunodeficiency virus type 1 envelope structure in the induction of broadly neutralizing antibodies.What the shark immune system can and cannot provide for the expanding design landscape of immunotherapy.Shark variable new antigen receptor biologics - a novel technology platform for therapeutic drug development.Structural insights and biomedical potential of IgNAR scaffolds from sharks.Single-domain antibodies for biomedical applications.Analysis of the binding loops configuration and surface adaptation of different crystallized single-domain antibodies in response to various antigens.Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein-protein binding free energies and re-rank binding poses generated by protein-protein docking.Dual beneficial effect of interloop disulfide bond for single domain antibody fragments.Therapeutic Potential of Shark Anti-ICOSL VNAR Domains is Exemplified in a Murine Model of Autoimmune Non-Infectious Uveitis.Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human.Immunogenetic factors driving formation of ultralong VH CDR3 in Bos taurus antibodies.Generation of Semi-Synthetic Shark IgNAR Single-Domain Antibody Libraries.The Unusual Genetics and Biochemistry of Bovine Immunoglobulins.Single-Domain Antibodies and the Promise of Modular Targeting in Cancer Imaging and Treatment.In silico-designed mutations increase variable new-antigen receptor single-domain antibodies for VEGF165 neutralization.Anti-ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen-Induced Mouse Model of Rheumatoid Arthritis
P2860
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P2860
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
description
2007 nî lūn-bûn
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2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
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2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
@ast
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
@en
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
@nl
type
label
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
@ast
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
@en
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
@nl
prefLabel
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
@ast
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
@en
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
@nl
P2093
P3181
P1476
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding
@en
P2093
Ian A Wilson
Petra Verdino
Robyn L Stanfield
P304
P3181
P356
10.1016/J.JMB.2006.12.045
P407
P577
2006-12-22T00:00:00Z