A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera - Wikidata - awgldk - TriplyDB

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

http://www.wikidata.org/entity/Q27643729

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Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer Insights into the Conformational Variability and Regulation of Human Nek2 Kinase Discovery of 4-Amino-1-(7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase Crystal Structure of a Human I B Kinase Asymmetric Dimer The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Crystal structure of human CDC7 kinase in complex with its activator DBF4 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB Mimic Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51 Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway Quantum mechanical pairwise decomposition analysis of protein kinase B inhibitors: validating a new tool for guiding drug design Chiral kinase inhibitors.Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway.Advances in fragment-based drug discovery platforms.Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.Clinical development of phosphatidylinositol-3 kinase pathway inhibitors Protein kinase-inhibitor database: structural variability of and inhibitor interactions with the protein kinase P-loop.Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930.Measuring and interpreting the selectivity of protein kinase inhibitors Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases.Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response Binding selectivity studies of PKBα using molecular dynamics simulation and free energy calculations.AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth.Inhibitor hijacking of Akt activation.AKT capture by feline leukemia virus.Synthesis and evaluation of indazole based analog sensitive Akt inhibitors Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide.Theory of docking scores and its application to a customizable scoring function.In search of AKT kinase inhibitors as anticancer agents: structure-based design, docking, and molecular dynamics studies of 2,4,6-trisubstituted pyridines.

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A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

http://www.wikidata.org/entity/Q27643729

description

2007 nî lūn-bûn

@nan

2007 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի մարտին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

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name

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

@ast

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

@en

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

@en-gb

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

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type

label

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

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A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

@en

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

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A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

@nl

prefLabel

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

@ast

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

@en

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

@en-gb

A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

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J.JMB.2007.01.004

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Journal of Molecular Biology

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A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera

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Brent Graham

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Christopher C F Hamlett

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David Barford

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Harren Jhoti

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Ian Collins

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Marcel L Verdonk

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Michelle D Garrett

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Steven J Woodhead

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Susanne Saalau-Bethell

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Tatiana McHardy

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