about
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAFControl of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinaseDynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2Fine-tuning multiprotein complexes using small moleculesTen things you should know about protein kinases: IUPHAR Review 14Principles of allosteric interactions in cell signalingDrugs for allosteric sites on receptorsTargeted therapies in development for non-small cell lung cancerCrystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase InhibitionChemical genetic strategy for targeting protein kinases based on covalent complementarityActive site profiling reveals coupling between domains in SRC-family kinasesAn ATP-site on-off switch that restricts phosphatase accessibility of AktStructure-Guided Inhibitor Design Expands the Scope of Analog-Sensitive Kinase TechnologyStaurosporine-Derived Inhibitors Broaden the Scope of Analog-Sensitive Kinase TechnologyAn ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 PseudokinaseConformation-Selective ATP-Competitive Inhibitors Control Regulatory Interactions and Noncatalytic Functions of Mitogen-Activated Protein KinasesCrystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motifProtein kinase C: poised to signalModulation of the Akt pathway reveals a novel link with PERK/eIF2α, which is relevant during hypoxiaThe p70S6K Specific Inhibitor PF-4708671 Impedes Non-Small Cell Lung Cancer GrowthRAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAFPI3K and cancer: lessons, challenges and opportunitiesA putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway.Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyveA chemical epitope-targeting strategy for protein capture agents: the serine 474 epitope of the kinase Akt2.Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexityChiral kinase inhibitors.Phosphatidylinositol 4,5-bisphosphate-specific AKT1 is oncogenic.Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.Protein kinase C-{delta} regulates the subcellular localization of Shc in H2O2-treated cardiomyocytes.Membrane docking geometry of GRP1 PH domain bound to a target lipid bilayer: an EPR site-directed spin-labeling and relaxation study.2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.Shedding light on local kinase activationMutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies.Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads.AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activityRequirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency.AZD5363 Inhibits Inflammatory Synergy between Interleukin-17 and Insulin/Insulin-Like Growth Factor 1InterAKTions with FKBPs--mutational and pharmacological exploration.
P2860
Q24298749-11216430-B10F-49C7-B865-5AD85D7CB144Q24317685-F329DBF3-CB37-4D8C-AE41-6E8E54C8DDFCQ24634071-293E36B8-E553-4936-90B2-71574CF96091Q26822675-E6B04DF9-B482-4AC0-8AA7-7CED0A802B28Q26849417-038E53AD-30E1-4C81-ABC2-CC8FC8F38BBAQ26996431-A991329B-DC10-4BFE-B0AF-85359DF2495FQ27006721-3B77A01D-3F7F-452B-BDEB-CE53F8C0D2AFQ27022852-15D9FBB1-8822-4126-BE78-08CA3D945F58Q27664839-D1EA8CE1-7FCE-4F9F-859F-7EEAD2479547Q27671824-90586EE5-7B6E-407F-AB49-5B8BB934E819Q27675080-FB8B125B-8798-4323-A78C-AE8BC4384ECEQ27678970-B5CFA304-E814-4282-843E-5050E77DD95AQ27679025-CE4396AA-51AD-4CD8-AE20-0995F402F3C0Q27680486-A57ACA38-CCF8-4EF5-AAA2-5DBCB53CAE68Q27682355-F051D25E-E7FD-4309-B2E4-F6A5E49FA333Q27682963-61741ABD-396B-4C07-9A36-64391E578475Q27684745-93687B63-ADBB-48B5-AA0F-35B41D727562Q28265620-6B9A05B5-EB75-4B7B-AE4D-3A98556E9BF4Q28534963-52147638-66F8-4B96-96EB-492B3A990571Q28552535-28462678-7372-4404-9DC6-0C0AE4FC2173Q29616828-4C977A85-6C1A-42D8-ADFC-FA6ED37B8B29Q30080017-05347514-5A80-4E3D-978E-07213FCBFC39Q31010361-710C9B63-ECA7-452A-9A93-D60D6EC70663Q33556119-63D1159B-2B15-4469-8110-F03E8DD600FAQ33700520-C9885DD0-2F9F-46C7-954D-DC43CC99456CQ33760966-C30332AC-C556-4C59-903B-53C166FE7D16Q33777656-436C4ECD-130A-4EDB-813A-AD2810BBEDF6Q33811207-E98F47BD-9B0B-4FC6-9CA3-40557BD69917Q33823535-673ED1D5-1F90-482C-B860-F596514A8F5AQ33920097-196DBD1D-CE15-43DC-9DF9-CCBB09FCB329Q34211714-4AA2A2A1-59FC-462B-B576-4CCC2C35B934Q34221530-4A78F15E-B083-4777-BA58-92279CAB85D0Q34243209-256DFBB2-3469-4688-8225-B6FA2F4615B8Q34340281-863F6229-F7E4-45C0-AAFB-264B42EECF22Q34365949-F7638A0C-0B73-4739-91E0-78C56C0D5EF3Q34493715-C260CDB1-E6AE-4224-A7FC-112C0732F3CAQ34511038-8F6DF272-165A-4B8B-9833-CA5CDEC27D5FQ34572866-0A87D00F-62AD-492A-B813-265CE9DC5CABQ34595624-8B367805-5F02-4A84-AB21-9808CB9E98C3Q34612149-46D630E1-4644-47F2-B2E6-973D6A292451
P2860
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Inhibitor hijacking of Akt activation.
@en
Inhibitor hijacking of Akt activation.
@nl
type
label
Inhibitor hijacking of Akt activation.
@en
Inhibitor hijacking of Akt activation.
@nl
prefLabel
Inhibitor hijacking of Akt activation.
@en
Inhibitor hijacking of Akt activation.
@nl
P2093
P2860
P356
P1476
Inhibitor hijacking of Akt activation.
@en
P2093
Brian Aizenstein
Chao Zhang
Daniel C Gray
Dorothea Fiedler
Kevan M Shokat
Randy Hoffman
Tatsuya Okuzumi
P2860
P2888
P304
P356
10.1038/NCHEMBIO.183
P577
2009-05-24T00:00:00Z