Structure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates
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Short linear motifs - ex nihilo evolution of protein regulationIntermolecular Interactions in a 44 kDa Interferon−Receptor Complex Detected by Asymmetric Reverse-Protonation and Two-Dimensional NOESYObservation of Intermolecular Interactions in Large Protein Complexes by 2D-Double Difference Nuclear Overhauser Enhancement Spectroscopy: Application to the 44 kDa Interferon–Receptor ComplexThe Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of CalcineurinBalanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signalingThe Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and DiseasesCalcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl IsomerizationHigh-throughput screening of one-bead-one-compound libraries: identification of cyclic peptidyl inhibitors against calcineurin/NFAT interaction.Structure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction.The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity.NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound statesThe RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators.Recent progress on the structure of Ser/Thr protein phosphatases.Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.Functional diversity and pharmacological profiles of the FKBPs and their complexes with small natural ligands.Transient disorder: Calcineurin as an example.Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity.The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain.Physical interaction between calcineurin and Cav3.2 T-type Ca2+ channel modulates their functions.Calcineurin binds and dephosphorylates NFATIdentification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding partners.
P2860
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P2860
Structure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structure of the Calcineurin-N ...... on NMR and Crystal Coordinates
@ast
Structure of the Calcineurin-N ...... on NMR and Crystal Coordinates
@en
Structure of the Calcineurin-N ...... on NMR and Crystal Coordinates
@nl
type
label
Structure of the Calcineurin-N ...... on NMR and Crystal Coordinates
@ast
Structure of the Calcineurin-N ...... on NMR and Crystal Coordinates
@en
Structure of the Calcineurin-N ...... on NMR and Crystal Coordinates
@nl
prefLabel
Structure of the Calcineurin-N ...... on NMR and Crystal Coordinates
@ast
Structure of the Calcineurin-N ...... on NMR and Crystal Coordinates
@en
Structure of the Calcineurin-N ...... on NMR and Crystal Coordinates
@nl
P2093
P2860
P3181
P1433
P1476
Structure of the calcineurin-N ...... on NMR and crystal coordinates
@en
P2093
Gerhard Wagner
Michael H A Roehrl
Zhen-Yu J Sun
P2860
P304
P3181
P356
10.1016/J.STR.2007.03.015
P50
P577
2007-05-01T00:00:00Z