Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)
about
Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugsIdentification of intracellular carriers for the endocannabinoid anandamideCrystallographic study of FABP5 as an intracellular endocannabinoid transporterTreatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinaseDevelopment of a radioiodinated triazolopyrimidine probe for nuclear medical imaging of fatty acid binding protein 4Binding modes of three inhibitors 8CA, F8A and I4A to A-FABP studied based on molecular dynamics simulationAll-Purpose Containers? Lipid-Binding Protein - Drug InteractionsThe Concise Guide to PHARMACOLOGY 2013/14: overview.Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets.Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1.Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases.Structural analysis of ibuprofen binding to human adipocyte fatty-acid binding protein (FABP4)Fatty acid binding protein 4 regulates intracellular lipid accumulation in human trophoblasts.Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia.Hydrogen-bonded His93 as a sensitive probe for identifying inhibitors of the endocannabinoid transport protein FABP7.Inhibition of tumor growth by a newly-identified activator for epidermal fatty acid binding proteinTargeting epidermal fatty acid binding protein for treatment of experimental autoimmune encephalomyelitis.Small lipid-binding proteins in regulating endothelial and vascular functions: focusing on adipocyte fatty acid binding protein and lipocalin-2.Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice.Evidence for bidirectional endocannabinoid transport across cell membranesFatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury.Binding of small-molecule ligands to proteins: "what you see" is not always "what you get".Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy.Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity.Chemical Genetic Approaches for the Investigation of Neutral Lipid Metabolism.Lipid chaperones and metabolic inflammation.Adipokines: Potential Therapeutic Targets for Vascular Dysfunction in Type II Diabetes Mellitus and Obesity.Interaction Analysis of FABP4 Inhibitors by X-ray Crystallography and Fragment Molecular Orbital Analysis.Fatty Acid-binding Proteins Interact with Comparative Gene Identification-58 Linking Lipolysis with Lipid Ligand Shuttling.A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target.Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin's glucose-lowering effects.BMS309403 directly suppresses cardiac contractile function.Vasculo-protective effect of BMS-309403 is independent of its specific inhibition of fatty acid-binding protein 4.Exogenous fatty acid binding protein 4 promotes human prostate cancer cell progression.Molecular Dynamics Exploration of Selectivity of Dual Inhibitors 5M7, 65X, and 65Z toward Fatty Acid Binding Proteins 4 and 5
P2860
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P2860
Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Potent and selective biphenyl ...... y acid binding protein (aFABP)
@ast
Potent and selective biphenyl ...... y acid binding protein (aFABP)
@en
Potent and selective biphenyl ...... y acid binding protein (aFABP)
@nl
type
label
Potent and selective biphenyl ...... y acid binding protein (aFABP)
@ast
Potent and selective biphenyl ...... y acid binding protein (aFABP)
@en
Potent and selective biphenyl ...... y acid binding protein (aFABP)
@nl
prefLabel
Potent and selective biphenyl ...... y acid binding protein (aFABP)
@ast
Potent and selective biphenyl ...... y acid binding protein (aFABP)
@en
Potent and selective biphenyl ...... y acid binding protein (aFABP)
@nl
P2093
P1476
Potent and selective biphenyl ...... y acid binding protein (aFABP)
@en
P2093
Bruce L Jacobson
David R Magnin
David S Taylor
Donna Bassolino-Klimas
Jeffrey A Robl
Kevin Kish
Leonard P Adam
Ligaya Simpkins
Manorama Patel
Prakash Taunk
P304
P356
10.1016/J.BMCL.2006.12.044
P407
P577
2007-06-15T00:00:00Z