Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design - Wikidata - awgldk - TriplyDB

Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

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Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy Crystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma brucei In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein fromClostridium difficile The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations Computational identification of uncharacterized cruzain binding sites In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plants A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets Vasohibins: new transglutaminase-like cysteine proteases possessing a non-canonical Cys-His-Ser catalytic triad A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target.Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target.Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness.In vitro and in vivo trypanocidal effects of the cyclopalladated compound 7a, a drug candidate for treatment of Chagas' disease.Novel cruzain inhibitors for the treatment of Chagas' disease.Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.Centenary celebrations article: Cysteine proteases of human malaria parasites.Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors Structure-function of falcipains: malarial cysteine proteases.Functionalization of immunostimulating complexes (ISCOMs) with lipid vinyl sulfones and their application in immunological techniques and therapy.Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection Trypanocidal drugs: mechanisms, resistance and new targets.Proteases as regulators of pathogenesis: examples from the Apicomplexa.Molecular recognition in chemical and biological systems.Predicting binding modes of reversible peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships.Cytotoxicity and sustained release of modified divinylsulfone from silk based 3D construct.Highly predictive hologram QSAR models of nitrile-containing cruzain inhibitors.Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action.Molecular docking and 3D-quantitative structure activity relationship analyses of peptidyl vinyl sulfones: Plasmodium Falciparum cysteine proteases inhibitors.Analysis of non-peptidic compounds as potential malarial inhibitors against Plasmodial cysteine proteases via integrated virtual screening workflow.Optimization of peptidyl allyl sulfones as clan CA cysteine protease inhibitors.Automated molecule editing in molecular design.Gold-catalyzed intermolecular C-S bond formation: efficient synthesis of α-substituted vinyl sulfones.Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.Structural features of falcipain-3 inhibitors: an in silico study.

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

http://www.wikidata.org/entity/Q27646557

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

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Journal of Biological Chemistry

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

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Charles S Craik

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Christopher J Farady

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Conor R Caffrey

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Elizabeth Hansell

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Iain D Kerr

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Linda S Brinen

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Mathias Rickert

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P2860

Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease

Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain

The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family

Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity ‡

Coot: model-building tools for molecular graphics

Phasercrystallographic software

Refinement of macromolecular structures by the maximum-likelihood method

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Philip J Rosenthal

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