Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy - Wikidata - awgldk - TriplyDB

Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy

Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy

http://www.wikidata.org/entity/Q27659045

about

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease Crystal Structures of TbCatB and Rhodesain, Potential Chemotherapeutic Targets and Major Cysteine Proteases of Trypanosoma brucei Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes The impact of click chemistry in medicinal chemistry.Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.Drug discovery for neglected tropical diseases at the Sandler Center.New approaches for dissecting protease functions to improve probe development and drug discovery Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.Advances in Chagas disease drug development: 2009-2010 Reversible cysteine protease inhibitors show promise for a Chagas disease cure.Microbial and fungal protease inhibitors--current and potential applications.Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease.Potential new clinical therapies for Chagas disease.Therapeutical approaches under investigation for treatment of Chagas disease.Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease Asymmetric synthesis of amines using tert-butanesulfinamide.Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics.Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor.Structural design, synthesis and structure-activity relationships of thiazolidinones with enhanced anti-Trypanosoma cruzi activity.Cysteine proteases in protozoan parasites Rational Selection of Anti-Microbial Drug Targets: Unique or Conserved?

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P2860

Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy

http://www.wikidata.org/entity/Q27659045

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Nonpeptidic Tetrafluorophenoxy ...... or Chagas Disease Chemotherapy

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Nonpeptidic Tetrafluorophenoxy ...... or Chagas Disease Chemotherapy

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Nonpeptidic Tetrafluorophenoxy ...... or Chagas Disease Chemotherapy

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type

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Nonpeptidic Tetrafluorophenoxy ...... or Chagas Disease Chemotherapy

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Nonpeptidic Tetrafluorophenoxy ...... or Chagas Disease Chemotherapy

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Nonpeptidic Tetrafluorophenoxy ...... or Chagas Disease Chemotherapy

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Nonpeptidic Tetrafluorophenoxy ...... or Chagas Disease Chemotherapy

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Nonpeptidic Tetrafluorophenoxy ...... or Chagas Disease Chemotherapy

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Nonpeptidic Tetrafluorophenoxy ...... or Chagas Disease Chemotherapy

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Journal of Medicinal Chemistry

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Nonpeptidic Tetrafluorophenoxy ...... or Chagas Disease Chemotherapy

@en

P2093

Iain D Kerr

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Jonathan A Ellman

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Juan C Engel

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Katrien Brak

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Kenny Ang

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Kimberly T Barrett

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Linda S Brinen

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Moumita Debnath

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Nobuhiro Fuchi

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Patricia S Doyle

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P2860

Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease

Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain

Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases

Coot: model-building tools for molecular graphics

Refinement of macromolecular structures by the maximum-likelihood method

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1763-73

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10.1021/JM901633V

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4

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53

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James H McKerrow

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2010-02-25T00:00:00Z

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41100956

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20088534

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2838180

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