Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor - Wikidata - awgldk - TriplyDB

Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor

Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor

http://www.wikidata.org/entity/Q27647924

about

Caught in self-interaction: evolutionary and functional mechanisms of protein homooligomerization Molecular basis for dimer formation of TRβ variant D355R Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate Identification of a new hormone-binding site on the surface of thyroid hormone receptor High-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probe Mechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric states Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2 Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor.Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.Structure of the homodimeric androgen receptor ligand-binding domain Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor.Probing the Complex Binding Modes of the PPARγ Partial Agonist 2-Chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy.An alternate binding site for PPARγ ligands Similarities and differences between two modes of antagonism of the thyroid hormone receptor.A covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid β.Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.Fluorescence polarization assays in high-throughput screening and drug discovery: a review Differential effects of TR ligands on hormone dissociation rates: evidence for multiple ligand entry/exit pathways.(-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β.Allosteric modulation as a unifying mechanism for receptor function and regulation.

P2860

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P2860

Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor

http://www.wikidata.org/entity/Q27647924

description

2007 nî lūn-bûn

@nan

2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Structural insight into the mo ...... o the thyroid hormone receptor

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Structural insight into the mo ...... o the thyroid hormone receptor

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Structural insight into the mo ...... o the thyroid hormone receptor

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type

label

Structural insight into the mo ...... o the thyroid hormone receptor

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Structural insight into the mo ...... o the thyroid hormone receptor

@en

Structural insight into the mo ...... o the thyroid hormone receptor

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prefLabel

Structural insight into the mo ...... o the thyroid hormone receptor

@ast

Structural insight into the mo ...... o the thyroid hormone receptor

@en

Structural insight into the mo ...... o the thyroid hormone receptor

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P1433

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P1433

Molecular Endocrinology

P1476

Structural insight into the mo ...... o the thyroid hormone receptor

@en

P2093

Ellena Mar

http://www.w3.org/2001/XMLSchema#string

Eva Estébanez-Perpiñá

http://www.w3.org/2001/XMLSchema#string

John D Baxter

http://www.w3.org/2001/XMLSchema#string

Justin Blethrow

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Kevin J Phillips

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Leggy A Arnold

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Marie Togashi

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Natalia Jouravel

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Paul Webb

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Phuong Nguyen

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P304

2919-28

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P31

scholarly article

P356

10.1210/ME.2007-0174

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12

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21

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2007-12-01T00:00:00Z

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6017694

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P698

17823305

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