about
A compound-based proteomic approach discloses 15-ketoatractyligenin methyl ester as a new PPARγ partial agonist with anti-proliferative abilityPoLi: A Virtual Screening Pipeline Based on Template Pocket and Ligand Similarity.Identification of an allosteric binding site for RORγt inhibition.Protein Footprinting Comes of Age: Mass Spectrometry for Biophysical Structure Assessment.Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes.Applications of hydrogen/deuterium exchange MS from 2012 to 2014.Deconvolution of Complex 1D NMR Spectra Using Objective Model SelectionPharmacological repression of PPARγ promotes osteogenesisStructural mechanism for signal transduction in RXR nuclear receptor heterodimers.Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.Structural review of PPARγ in complex with ligands: Cartesian- and dihedral angle principal component analyses of X-ray crystallographic data.Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndromeβ-arrestin-1 contributes to brown fat function and directly interacts with PPARα and PPARγ.Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1.Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro.HDX-MS guided drug discovery: small molecules and biopharmaceuticals.Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor.Probing the Complex Binding Modes of the PPARγ Partial Agonist 2-Chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy.Peroxisome proliferator activating receptor-γ and the podocyte.Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.Structural and Dynamical Insight into PPARγ Antagonism: In Silico Study of the Ligand-Receptor Interactions of Non-Covalent Antagonists.Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy.Dibutyltin Compounds Effects on PPARγ/RXRα Activity, Adipogenesis, and Inflammation in Mammalians Cells.Divergent synthesis and identification of the cellular targets of deoxyelephantopins.A structural perspective on nuclear receptors as targets of environmental compounds.Dihydrosanguinarine Enhances Glucose Uptake in Mouse 3T3-L1 Cells.Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA.An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery.A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome.Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammation-driven neuronal deterioration in experimental Parkinson's disease: possible involvement of different binding sites at the PPARγ receptor.Allosteric modulation as a unifying mechanism for receptor function and regulation.Defining a conformational ensemble that directs activation of PPARγ.A structural mechanism for directing corepressor-selective inverse agonism of PPARγSignaling Mechanisms of Selective PPAR Modulators in Alzheimer's Disease
P2860
Q28818450-9C4AFAFF-A08D-4420-949D-CDA96B1B4D53Q30377334-374EDE5A-D2B7-4F78-BE2F-6F875B1D41C7Q30394306-EA41BB87-3FEA-438C-80A7-F26C3B2801D9Q30399662-3D814F10-C4DC-48D6-B39D-C258A1E9C2B8Q34315432-3B706F44-D871-4EC0-B472-CE34DEAB0122Q34870033-B685273D-10E8-4ED0-88AD-318FB920C65EQ35737665-407EA34B-E261-47F8-AC08-472BC41ED473Q35754510-89748A01-55A5-488C-95F0-0B84E6618F0CQ35990304-3F03D712-F6F5-4F8C-831A-E43F49E10133Q36059350-A5D2C31B-FF6F-495F-A995-E9F138217198Q36381221-9190D86B-8CE8-4C55-812A-AC9A4B0453ADQ36686554-CAA9A1EA-3AFB-416C-A87B-4A3F793A6A2FQ37005673-6BFAE230-78CC-4518-8010-3091ADFFFFA8Q37099077-8C6ACF64-4271-4B38-9E3D-798F1634A1FBQ37609686-D90021BA-A051-4550-BD15-CA391FA985D4Q38245359-A685675F-3BA7-4F03-AA0C-CBB28EFEE58DQ38433439-8C6226FB-41AF-4146-8131-FD39E6415907Q38435324-DEBA6188-92A7-498D-907F-8758FE8BF82DQ38815188-F0B21E69-D81B-459F-BEDE-FBC6A5BC289BQ40075003-7B30B5A9-2FAB-4584-A510-F1123EDBD055Q40726727-0CB1C30A-1592-4016-9825-B26FFF6AFC1EQ41046166-536B48A0-4F88-4EB3-95D7-FCA0ACB585FAQ41203823-5A4CC0A3-663F-419A-BE3C-F8C662DBF4D7Q41504689-75033CB7-EC8F-4658-8496-AC427ABCCCFDQ43249416-53AD99E0-C230-448C-9609-75F458B53699Q47095014-6AC77EFA-4335-4D28-A133-50108DF8FCCFQ47825752-6308FFFF-0E65-4B28-9597-FBEE7C4AD5C3Q47996927-06FB2A4B-B5B8-4466-A473-E4B14A1FE20BQ48138914-CB35A63A-5130-4B01-9464-BDC17052BBFDQ49433973-A2960B36-A3DC-4114-8500-AE5B3C897E08Q53082766-CCC9C282-D401-4724-BA7C-9C35248E6446Q55379909-4AC11884-4990-4491-9C97-A949B5F0AA03Q58586525-6E891223-2F13-4C3B-9533-EEA5D4D0445BQ58699276-CF78E1D1-D23A-4960-80ED-B26B6716141D
P2860
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
An alternate binding site for PPARγ ligands
@en
type
label
An alternate binding site for PPARγ ligands
@en
prefLabel
An alternate binding site for PPARγ ligands
@en
P2093
P2860
P356
P1476
An alternate binding site for PPARγ ligands
@en
P2093
Anne-Laure Blayo
Dana S Kuruvilla
David P Marciano
Douglas J Kojetin
Pankaj Kumar Giri
Patrick R Griffin
Theodore M Kamenecka
Travis S Hughes
Youseung Shin
P2860
P2888
P356
10.1038/NCOMMS4571
P407
P577
2014-04-07T00:00:00Z
P5875
P6179
1026160220