A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment
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A rescue act: Translesion DNA synthesis past N(2) -deoxyguanosine adducts3′-Intercalation of a N 2 -dG 1 R - trans - anti -Benzo[ c ]phenanthrene DNA Adduct in an Iterated (CG) 3 RepeatVersatility of Y-family Sulfolobus solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N2-Alkylguanine AdductsStructural basis of error-prone replication and stalling at a thymine base by human DNA polymerase ιImpact of Conformational Heterogeneity of OxoG Lesions and Their Pairing Partners on Bypass Fidelity by Y Family PolymerasesMechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4Structure of the 1, N 2 -Etheno-2′-deoxyguanosine Lesion in the 3′-G(εdG)T-5′ Sequence Opposite a One-Base DeletionStructural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4Structure and mechanism of human DNA polymerase ηThe Y-Family DNA Polymerase Dpo4 Uses a Template Slippage Mechanism To Create Single-Base DeletionsImplications for Damage Recognition during Dpo4-Mediated Mutagenic Bypass of m1G and m3C LesionsReplication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymeraseStructural Mechanism of Replication Stalling on a Bulky Amino-Polycyclic Aromatic Hydrocarbon DNA Adduct by a Y Family DNA PolymeraseMechanistic investigation of the bypass of a bulky aromatic DNA adduct catalyzed by a Y-family DNA polymeraseAn overview of Y-Family DNA polymerases and a case study of human DNA polymerase ηThe N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesionsUmuD(2) inhibits a non-covalent step during DinB-mediated template slippage on homopolymeric nucleotide runs.Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4)Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase.Dynamic conformational change regulates the protein-DNA recognition: an investigation on binding of a Y-family polymerase to its target DNA.Kinetic analysis of the bypass of a bulky DNA lesion catalyzed by human Y-family DNA polymerases.Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase.Quantitative analysis of the mutagenic potential of 1-aminopyrene-DNA adduct bypass catalyzed by Y-family DNA polymerases.Epigenetic influences in the aetiology of cancers arising from breast and prostate: a hypothesised transgenerational evolution in chromatin accessibilityMechanism of aromatic amine carcinogen bypass by the Y-family polymerase, Dpo4.Y-family DNA polymerases and their role in tolerance of cellular DNA damage.DNA adduct structure-function relationships: comparing solution with polymerase structures.Lesion processing: high-fidelity versus lesion-bypass DNA polymerasesFrameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formationVariants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct.Structural diversity of the Y-family DNA polymerases.Chemistry and structural biology of DNA damage and biological consequencesRecent insight into the kinetic mechanisms and conformational dynamics of Y-Family DNA polymerases.Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ.Pre-steady-state kinetic investigation of bypass of a bulky guanine lesion by human Y-family DNA polymerases.Y-Family DNA polymerases may use two different dNTP shapes for insertion: a hypothesis and its implicationsMechanistic studies of the bypass of a bulky single-base lesion catalyzed by a Y-family DNA polymerase.Architecture of y-family DNA polymerases relevant to translesion DNA synthesis as revealed in structural and molecular modeling studies.Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase.Amino acid architecture that influences dNTP insertion efficiency in Y-family DNA polymerase V of E. coli.
P2860
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P2860
A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment
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2007 nî lūn-bûn
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2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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A structural gap in Dpo4 suppo ...... through template misalignment
@ast
A structural gap in Dpo4 suppo ...... through template misalignment
@en
A structural gap in Dpo4 suppo ...... through template misalignment
@nl
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label
A structural gap in Dpo4 suppo ...... through template misalignment
@ast
A structural gap in Dpo4 suppo ...... through template misalignment
@en
A structural gap in Dpo4 suppo ...... through template misalignment
@nl
prefLabel
A structural gap in Dpo4 suppo ...... through template misalignment
@ast
A structural gap in Dpo4 suppo ...... through template misalignment
@en
A structural gap in Dpo4 suppo ...... through template misalignment
@nl
P2093
P2860
P3181
P356
P1476
A structural gap in Dpo4 suppo ...... through template misalignment
@en
P2093
Donald M Jerina
Guangxin Xing
Haruhiko Yagi
Jacob Bauer
Jane M Sayer
P2860
P304
P3181
P356
10.1073/PNAS.0700717104
P407
P577
2007-09-18T00:00:00Z