Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association - Wikidata - awgldk - TriplyDB

Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association

Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association

http://www.wikidata.org/entity/Q27648873

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Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2 Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis Molecular machines governing exocytosis of synaptic vesicles The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer Molecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusion Ring-like oligomers of Synaptotagmins and related C2 domain proteins The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding.Cloning, expression, purification, crystallization and preliminary X-ray diffraction crystallographic study of human synaptotagmin 5 C2A domain Synaptotagmin 1 and SNAREs form a complex that is structurally heterogeneous.Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridging Conformation and membrane position of the region linking the two C2 domains in synaptotagmin 1 by site-directed spin labeling.A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology.Single-molecule studies of the neuronal SNARE fusion machinery.Quantitative analysis of synaptic release at the photoreceptor synapse Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission.Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex.Calcium sensitive ring-like oligomers formed by synaptotagmin Negative coupling as a mechanism for signal propagation between C2 domains of synaptotagmin I.Three-dimensional molecular modeling with single molecule FRET.Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Calcium binding promotes conformational flexibility of the neuronal Ca(2+) sensor synaptotagmin.An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission.Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission.Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1.Different states of synaptotagmin regulate evoked versus spontaneous release.Synaptic vesicle fusion.Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release.The c2 domains of human synaptotagmin 1 have distinct mechanical properties Structure-function relationships in calpains.The blockade of the neurotransmitter release apparatus by botulinum neurotoxins.Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7 Circular oligomerization is an intrinsic property of synaptotagmin.Differential Membrane Binding Mechanics of Synaptotagmin Isoforms Observed in Atomic Detail.A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion.Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis.Essential role of the CBD1-CBD2 linker in slow dissociation of Ca2+ from the regulatory two-domain tandem of NCX1.The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate.Synaptotagmin perturbs the structure of phospholipid bilayers.A computational model of a strongly facilitating synapse.Hypothesis - buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission.

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P2860

Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association

http://www.wikidata.org/entity/Q27648873

description

2007 nî lūn-bûn

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2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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Structure of human synaptotagm ...... als a novel domain association

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Structure of human synaptotagm ...... als a novel domain association

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J Justin Robert

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Kerry L Fuson

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Miguel Montes

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R Bryan Sutton

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P2860

Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel

Role of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle docking

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?

Processing of X-ray diffraction data collected in oscillation mode

Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+

Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?

Coot: model-building tools for molecular graphics

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scholarly article

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4498880

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10.1021/BI701651K

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45

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46

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17956130

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5975968

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