The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate.
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Alternate splicing of dysferlin C2A confers Ca²⁺-dependent and Ca²⁺-independent binding for membrane repairDynamic binding mode of a Synaptotagmin-1-SNARE complex in solutionRAB-10 Promotes EHBP-1 Bridging of Filamentous Actin and Tubular Recycling Endosomes.Structure and calcium-binding studies of calmodulin-like domain of human non-muscle α-actinin-1.Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitmentA conformational switch in complexin is required for synaptotagmin to trigger synaptic fusionQuantitation of the calcium and membrane binding properties of the C2 domains of dysferlinCis- and trans-membrane interactions of synaptotagmin-1Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-foldPtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium.Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strengthSynaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserineIn vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter releaseCalcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis.Viral infection controlled by a calcium-dependent lipid-binding module in ALIX.Characterization of the lipid binding properties of Otoferlin reveals specific interactions between PI(4,5)P2 and the C2C and C2F domains.Label-free microscale thermophoresis discriminates sites and affinity of protein-ligand bindingMicroscale thermophoresis quantifies biomolecular interactions under previously challenging conditionsThe WNKs: atypical protein kinases with pleiotropic actions.New insights into short-term synaptic facilitation at the frog neuromuscular junction.Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation.Copper binding affinity of the C2B domain of synaptotagmin-1 and its potential role in the nonclassical secretion of acidic fibroblast growth factor.Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Post-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1Calcium binding promotes conformational flexibility of the neuronal Ca(2+) sensor synaptotagmin.Lipid targeting domain with dual-membrane specificity that expands the diversity of intracellular targeting reactions.Controlling synaptotagmin activity by electrostatic screening.Calcium-dependent oligomerization of CAR proteins at cell membrane modulates ABA signalingRas GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes.Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1.NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I-relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1).Cell healing: Calcium, repair and regeneration.Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion.Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin.Survey of the year 2009: applications of isothermal titration calorimetry.Latest developments in experimental and computational approaches to characterize protein-lipid interactions.PI(4,5)P₂-binding effector proteins for vesicle exocytosis.Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7The Mechanisms and Functions of Synaptic Facilitation.The C2 domains of granuphilin are high-affinity sensors for plasma membrane lipids.
P2860
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P2860
The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
The Ca2+ affinity of synaptota ...... idylinositol 4,5-bisphosphate.
@en
The Ca2+ affinity of synaptota ...... idylinositol 4,5-bisphosphate.
@nl
type
label
The Ca2+ affinity of synaptota ...... idylinositol 4,5-bisphosphate.
@en
The Ca2+ affinity of synaptota ...... idylinositol 4,5-bisphosphate.
@nl
prefLabel
The Ca2+ affinity of synaptota ...... idylinositol 4,5-bisphosphate.
@en
The Ca2+ affinity of synaptota ...... idylinositol 4,5-bisphosphate.
@nl
P2860
P50
P356
P1476
The Ca2+ affinity of synaptota ...... idylinositol 4,5-bisphosphate.
@en
P2093
Anand Radhakrishnan
P2860
P304
25749-25760
P356
10.1074/JBC.M109.042499
P407
P577
2009-07-24T00:00:00Z