High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
about
ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural OverviewGenetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug TargetsGenetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and functionStructural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase InhibitorsStructure analysis reveals the flexibility of the ADAMTS-5 active siteStructure of human ADAM-8 catalytic domain complexed with batimastatADAMTS13 and von Willebrand factor interactions.The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor.Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13).Using fluorogenic peptide substrates to assay matrix metalloproteinases.Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.Emerging Roles of ADAMTSs in Angiogenesis and Cancer.Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: insights on ADAM functionAnalysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates.Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development.Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease.Inhibition of aggrecanases as a therapeutic strategy in osteoarthritis.Computational Insights into ADAMTS4, ADAMTS5 and MMP13 Inhibitor Selectivity.Molecular basis for the mechanism of action of an anti-TACE antibody.Design, synthesis, and preliminary biological evaluation of pyrrolo[3,4-c]quinolin-1-one and oxoisoindoline derivatives as aggrecanase inhibitors.High throughput protease profiling comprehensively defines active site specificity for thrombin and ADAMTS13.
P2860
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P2860
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
@ast
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
@en
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
@nl
type
label
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
@ast
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
@en
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
@nl
prefLabel
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
@ast
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
@en
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
@nl
P2093
P2860
P3181
P356
P1476
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
@en
P2093
Alfredo Tomasselli
Elizabeth C Arner
Huey-Sheng Shieh
Jeffery N Carroll
Jennifer M Williams
Joe F Wiese
Joseph W Leone
Karl J Mathis
Margaret H Marino
Micky D Tortorella
P2860
P304
P3181
P356
10.1074/JBC.M705879200
P407
P577
2007-11-08T00:00:00Z