Tyramine fragment binding to BACE-1

Tyramine fragment binding to BACE-1

Item
http://www.wikidata.org/entity/Q27649725
Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulationsThe major cockroach allergen Bla g 4 binds tyramine and octopamine.Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and XaperonesIntegrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process.Emerging role of surface plasmon resonance in fragment-based drug discovery.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseFragment screening by surface plasmon resonance.Recent progress in the drug discovery of non-peptidic BACE1 inhibitors.3D descriptors calculation and conformational search to investigate potential bioactive conformations, with application in 3D-QSAR and virtual screening in drug design.Computational analysis of BACE1-ligand complex crystal structures and linear discriminant analysis for identification of BACE1 inhibitors with anti P-glycoprotein binding property.Effect of pH and ligand charge state on BACE-1 fragment docking performance.Effect of sampling on BACE-1 ligands binding free energy predictions via MM-PBSA calculations.Fragment-based virtual screening approach and molecular dynamics simulation studies for identification of BACE1 inhibitor leads.Structure- and ligand-based drug design of novel p38-alpha MAPK inhibitors in the fight against the Alzheimer's disease.
P2860

Tyramine fragment binding to BACE-1

Item
http://www.wikidata.org/entity/Q27649725
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Tyramine fragment binding to BACE-1
@ast
Tyramine fragment binding to BACE-1
@en
Tyramine fragment binding to BACE-1
@nl
type
label
Tyramine fragment binding to BACE-1
@ast
Tyramine fragment binding to BACE-1
@en
Tyramine fragment binding to BACE-1
@nl
prefLabel
Tyramine fragment binding to BACE-1
@ast
Tyramine fragment binding to BACE-1
@en
Tyramine fragment binding to BACE-1
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Tyramine fragment binding to BACE-1
@en
P2093
P304
P31
P356
10.1016/J.BMCL.2008.01.032
P407
P433
P478
P50
P577
P698