Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope
about
Alzheimer's disease--a panorama glimpseGermline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragmentStructures of Aβ-Related Peptide−Monoclonal Antibody Complexes ,Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid -related Behavioral Deficits in a Mouse Model of Alzheimer DiseaseHis-tag binding by antibody C706 mimics β-amyloid recognitionBapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformationCrystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-βStructural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptideCrystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumabPeptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.Predicting a double mutant in the twilight zone of low homology modeling for the skeletal muscle voltage-gated sodium channel subunit beta-1 (Nav1.4 β1).Structural determination of Abeta25-35 micelles by molecular dynamics simulations.Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies.Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide.Anti-amyloidogenic properties of some phenolic compoundsDissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analoguesValidation and Characterization of a Novel Peptide That Binds Monomeric and Aggregated β-Amyloid and Inhibits the Formation of Neurotoxic Oligomers.Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease.Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin.Structure of N-terminal sequence Asp-Ala-Glu-Phe-Arg-His-Asp-Ser of Aβ-peptide with phospholipase A2 from venom of Andaman Cobra sub-species Naja naja sagittifera at 2.0 Å resolution.Conformational selection in amyloid-based immunotherapy: Survey of crystal structures of antibody-amyloid complexes.ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neuronsA coiled conformation of amyloid-β recognized by antibody C706.Shedding of APP limits its synaptogenic activity and cell adhesion properties.Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy.Mechanisms of recognition of amyloid-β (Aβ) monomer, oligomer, and fibril by homologous antibodies.Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.
P2860
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P2860
Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Amyloid-beta-anti-amyloid-beta ...... immunodominant B-cell epitope
@ast
Amyloid-beta-anti-amyloid-beta ...... immunodominant B-cell epitope
@en
Amyloid-beta-anti-amyloid-beta ...... immunodominant B-cell epitope
@nl
type
label
Amyloid-beta-anti-amyloid-beta ...... immunodominant B-cell epitope
@ast
Amyloid-beta-anti-amyloid-beta ...... immunodominant B-cell epitope
@en
Amyloid-beta-anti-amyloid-beta ...... immunodominant B-cell epitope
@nl
prefLabel
Amyloid-beta-anti-amyloid-beta ...... immunodominant B-cell epitope
@ast
Amyloid-beta-anti-amyloid-beta ...... immunodominant B-cell epitope
@en
Amyloid-beta-anti-amyloid-beta ...... immunodominant B-cell epitope
@nl
P2093
P50
P1476
Amyloid-beta-anti-amyloid-beta ...... immunodominant B-cell epitope
@en
P2093
Christopher J Bagley
Denise Galatis
Gabriela A N Crespi
Kevin J Barnham
Kwok S Wun
Luke A Miles
Michelle T Fodero-Tavoletti
P304
P356
10.1016/J.JMB.2007.12.036
P407
P577
2008-03-14T00:00:00Z