Insights into Oncogenic Mutations of Plexin-B1 Based on the Solution Structure of the Rho GTPase Binding Domain
about
Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPaseEffect of cancer-associated mutations in the PlexinB1 geneStructure and function of the intracellular region of the plexin-b1 transmembrane receptorModeling transmembrane domain dimers/trimers of plexin receptors: implications for mechanisms of signal transmission across the membraneCrystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestrationA Dual Binding Mode for RhoGTPases in Plexin SignallingA direct coupling between global and internal motions in a single domain protein? MD investigation of extreme scenarios.Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs)Loss of plexin-B3 in hepatocellular carcinoma.The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.Compensatory and long-range changes in picosecond-nanosecond main-chain dynamics upon complex formation: 15N relaxation analysis of the free and bound states of the ubiquitin-like domain of human plexin-B1 and the small GTPase Rac1.Tyrosine phosphorylation in semaphorin signalling: shifting into overdrive.Roles of Sema4D and Plexin-B1 in tumor progressionPlexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions.Molecular Dynamics Simulations Reveal Isoform Specific Contact Dynamics between the Plexin Rho GTPase Binding Domain (RBD) and Small Rho GTPases Rac1 and Rnd1.Combining NMR and molecular dynamics studies for insights into the allostery of small GTPase-protein interactions.Structure and dynamics analysis on plexin-B1 Rho GTPase binding domain as a monomer and dimer.Integrated computational approach to the analysis of NMR relaxation in proteins: application to ps-ns main chain 15N-1H and global dynamics of the Rho GTPase binding domain of plexin-B1.Analysis of 15N-1H NMR relaxation in proteins by a combined experimental and molecular dynamics simulation approach: picosecond-nanosecond dynamics of the Rho GTPase binding domain of plexin-B1 in the dimeric state indicates allosteric pathways.Characterizing Plexin GTPase Interactions Using Gel Filtration, Surface Plasmon Resonance Spectrometry, and Isothermal Titration Calorimetry.
P2860
Q24294818-8F017C8F-4434-48D1-B7E9-AABEF685AE7BQ24306887-3FEE2FAD-F58E-47A2-AC6C-62FC6CC3D556Q24309186-9B00B20F-5102-4F7D-9648-054AF5E35582Q27310828-E4A7C201-5FBB-417D-A2D8-CD054F0D2DBDQ27657229-CFE88D04-EB4E-4A89-9979-4537116A5E61Q27673776-5E04F131-5E3B-4FF5-932C-1870B1C60D94Q35079361-4BD059A7-03EA-4BB4-8060-9C314BD80DAFQ35110931-0F8AFBF6-A583-43AF-A2B6-82ABBE1A37B8Q35159658-7B385BE5-2CA0-422E-B19B-AC7202F87AB2Q35218537-AD78FEB8-1DAF-4B0E-990B-94D666D41769Q37154008-9DB72F68-A659-4DBD-B5EA-DDA509ADA41BQ37228375-B99640D7-FEDB-4068-A046-65D7844A5F78Q37790755-5ECE1600-E4AC-4A5A-BFBF-420C3A3096ACQ38022543-EC61F66D-85A2-47CF-87AD-14E1B14EF86FQ39012149-6BADD69E-6E7E-4565-99D5-ADF3D5A6BD5BQ42159319-D4F1E971-DD42-41D3-8C66-EA4DE96FC60CQ42277883-5E007021-BBA6-49DF-85FA-C92234BE5BB6Q42719047-8D397481-1961-4B25-AA71-FF03415F2E14Q43041951-CC2FCB58-6857-4F93-96A5-96271A0A0479Q51359776-9048308B-3162-4CDD-ABC9-1A52C98F0EC7
P2860
Insights into Oncogenic Mutations of Plexin-B1 Based on the Solution Structure of the Rho GTPase Binding Domain
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Insights into Oncogenic Mutati ...... the Rho GTPase Binding Domain
@ast
Insights into Oncogenic Mutati ...... the Rho GTPase Binding Domain
@en
Insights into Oncogenic Mutati ...... the Rho GTPase Binding Domain
@nl
type
label
Insights into Oncogenic Mutati ...... the Rho GTPase Binding Domain
@ast
Insights into Oncogenic Mutati ...... the Rho GTPase Binding Domain
@en
Insights into Oncogenic Mutati ...... the Rho GTPase Binding Domain
@nl
altLabel
Insights into oncogenic mutati ...... the Rho GTPase binding domain
@en
prefLabel
Insights into Oncogenic Mutati ...... the Rho GTPase Binding Domain
@ast
Insights into Oncogenic Mutati ...... the Rho GTPase Binding Domain
@en
Insights into Oncogenic Mutati ...... the Rho GTPase Binding Domain
@nl
P2860
P50
P1433
P1476
Insights into Oncogenic Mutati ...... the Rho GTPase Binding Domain
@en
P2093
Mehdi Bagheri Hamaneh
P2860
P304
P356
10.1016/J.STR.2007.12.012
P407
P577
2008-02-01T00:00:00Z