Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain - Wikidata - awgldk - TriplyDB

Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain

Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain

http://www.wikidata.org/entity/Q27648718

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Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1 Structural basis of semaphorin-plexin signalling RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules Effect of cancer-associated mutations in the PlexinB1 gene Structure and function of the intracellular region of the plexin-b1 transmembrane receptor RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor Understanding cell signalling systems: paving the way for new therapies Modeling transmembrane domain dimers/trimers of plexin receptors: implications for mechanisms of signal transmission across the membrane Insights into Oncogenic Mutations of Plexin-B1 Based on the Solution Structure of the Rho GTPase Binding Domain Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration A Dual Binding Mode for RhoGTPases in Plexin Signalling Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization Transmembrane recognition of the semaphorin co-receptors neuropilin 1 and plexin A1: coarse-grained simulations Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex A collaborative filtering approach for protein-protein docking scoring functions.Plexin-B1 activates NF-κB and IL-8 to promote a pro-angiogenic response in endothelial cells A generalized approach to sampling backbone conformations with RosettaDock for CAPRI rounds 13-19 Diverse functions for the semaphorin receptor PlexinD1 in development and disease.A cytosolic juxtamembrane interface modulates plexin A3 oligomerization and signal transduction.Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs)The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.Structural mechanisms of plexin signaling Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling The GTPase-deficient Rnd proteins are stabilized by their effectors.Class A Plexins Are Organized as Preformed Inactive Dimers on the Cell Surface Compensatory and long-range changes in picosecond-nanosecond main-chain dynamics upon complex formation: 15N relaxation analysis of the free and bound states of the ubiquitin-like domain of human plexin-B1 and the small GTPase Rac1.Tyrosine phosphorylation in semaphorin signalling: shifting into overdrive.Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology.Refinement of the primary hydration shell model for molecular dynamics simulations of large proteins.Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway.Transmembrane semaphorins: Multimodal signaling cues in development and cancer.Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions.Structures of Ras superfamily effector complexes: What have we learnt in two decades?Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts.Molecular Dynamics Simulations Reveal Isoform Specific Contact Dynamics between the Plexin Rho GTPase Binding Domain (RBD) and Small Rho GTPases Rac1 and Rnd1.Backbone assignment and secondary structure of Rnd1, an unusual Rho family small GTPase.Selection of near-native poses in CAPRI rounds 13-19.

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Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain

http://www.wikidata.org/entity/Q27648718

description

2007 nî lūn-bûn

@nan

2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

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2007年論文

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2007年論文

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2007年論文

@zh-hk

2007年論文

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2007年論文

@zh-tw

2007年论文

@wuu

name

Binding of Rac1, Rnd1, and Rho ...... the Plexin-B1 Effector Domain

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Binding of Rac1, Rnd1, and Rho ...... the Plexin-B1 Effector Domain

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Binding of Rac1, Rnd1, and Rho ...... the Plexin-B1 Effector Domain

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Binding of Rac1, Rnd1, and Rho ...... the Plexin-B1 Effector Domain

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Binding of Rac1, Rnd1, and Rho ...... the Plexin-B1 Effector Domain

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Binding of Rac1, Rnd1, and Rho ...... the Plexin-B1 Effector Domain

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Binding of Rac1, Rnd1, and Rho ...... the Plexin-B1 Effector Domain

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Binding of Rac1, Rnd1, and Rho ...... the Plexin-B1 Effector Domain

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Binding of Rac1, Rnd1, and Rho ...... the Plexin-B1 Effector Domain

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Journal of Biological Chemistry

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Binding of Rac1, Rnd1, and Rho ...... the Plexin-B1 Effector Domain

@en

P2093

Hee-Won Park

http://www.w3.org/2001/XMLSchema#string

Limin Shen

http://www.w3.org/2001/XMLSchema#string

Mei Li

http://www.w3.org/2001/XMLSchema#string

Preeti Chugha

http://www.w3.org/2001/XMLSchema#string

Rebecca S Alviani

http://www.w3.org/2001/XMLSchema#string

P2860

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates

Rho GTPases have diverse effects on the organization of the actin filament system

Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells

A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner

Structure of the semaphorin-3A receptor binding module

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D

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37215-24

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scholarly article

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10.1074/JBC.M703800200

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51

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282

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Prasanta K Hota

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2007-12-21T00:00:00Z

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5927598

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17916560

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2655321

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