A nuclear receptor-like pathway regulating multidrug resistance in fungi
about
MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expressionActivator Gcn4 employs multiple segments of Med15/Gal11, including the KIX domain, to recruit mediator to target genes in vivoImportance of Mediator complex in the regulation and integration of diverse signaling pathways in plantsMediator-dependent nuclear receptor functionTipping the balance both ways: drug resistance and virulence in Candida glabrataGain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulenceThe evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxificationIdentification, structure, and functional requirement of the Mediator submodule Med7N/31Structure and VP16 binding of the Mediator Med25 activator interaction domainUnfolding of the C-Terminal Domain of the J-Protein Zuo1 Releases Autoinhibition and Activates Pdr1-Dependent TranscriptionAllosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic CoreIdentification of a DNA-binding site for the transcription factor Haa1, required for Saccharomyces cerevisiae response to acetic acid stress.Differential roles of transcriptional mediator subunits in regulation of multidrug resistance gene expression in Saccharomyces cerevisiae.Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of γ-aminobutyrate responsive genes.Mechanism of Mediator recruitment by tandem Gcn4 activation domains and three Gal11 activator-binding domainsActivation of a poised RNAPII-dependent promoter requires both SAGA and mediator.The Mediator complex and transcription regulationMediator subunit Gal11p/MED15 is required for fatty acid-dependent gene activation by yeast transcription factor Oaf1pYeast biological networks unfold the interplay of antioxidants, genome and phenotype, and reveal a novel regulator of the oxidative stress responseA role for FACT in repopulation of nucleosomes at inducible genesSystematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genesNewer antibacterial drugs for a new century.Genetic Basis of Antifungal Drug ResistanceAn improved reversibly dimerizing mutant of the FK506-binding protein FKBPMicrobial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementationTra1 as a screening target for transcriptional activation domain discovery.Efflux in fungi: la pièce de résistanceFM reconstruction of non-uniformly sampled protein NMR data at higher dimensions and optimization by distillation.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase.Isolation of compensatory inhibitor domain mutants to novel activation domain variants using the split-ubiquitin screen.Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates.SAGA/ADA complex subunit Ada2 is required for Cap1- but not Mrr1-mediated upregulation of the Candida albicans multidrug efflux pump MDR1UPC2A is required for high-level azole antifungal resistance in Candida glabrata.The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression.Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.Pivotal role for a tail subunit of the RNA polymerase II mediator complex CgMed2 in azole tolerance and adherence in Candida glabrataNon-recognition-of-BTH4, an Arabidopsis mediator subunit homolog, is necessary for development and response to salicylic acid.Overcoming drug resistance by regulating nuclear receptors.Molecular recognition by the KIX domain and its role in gene regulation.
P2860
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P2860
A nuclear receptor-like pathway regulating multidrug resistance in fungi
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A nuclear receptor-like pathway regulating multidrug resistance in fungi
@ast
A nuclear receptor-like pathway regulating multidrug resistance in fungi
@en
A nuclear receptor-like pathway regulating multidrug resistance in fungi
@nl
type
label
A nuclear receptor-like pathway regulating multidrug resistance in fungi
@ast
A nuclear receptor-like pathway regulating multidrug resistance in fungi
@en
A nuclear receptor-like pathway regulating multidrug resistance in fungi
@nl
prefLabel
A nuclear receptor-like pathway regulating multidrug resistance in fungi
@ast
A nuclear receptor-like pathway regulating multidrug resistance in fungi
@en
A nuclear receptor-like pathway regulating multidrug resistance in fungi
@nl
P2093
P3181
P356
P1433
P1476
A nuclear receptor-like pathway regulating multidrug resistance in fungi
@en
P2093
Anders M Näär
Brendan P Cormack
Darrick K Li
Dominique P Frueh
Eleftherios Mylonakis
Fajun Yang
Gerhard Wagner
Jitendra K Thakur
Julia Breger
Kailash Gulshan
P2888
P304
P3181
P356
10.1038/NATURE06836
P407
P577
2008-04-01T00:00:00Z
P5875
P6179
1019681936