Overcoming drug resistance by regulating nuclear receptors.
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Biology of PXR: role in drug-hormone interactionsRole of pregnane X receptor in chemotherapeutic treatmentModulation of xenobiotic receptors by steroidsTargeting xenobiotic receptors PXR and CAR in human diseasesPregnane-10,2-carbolactones from a Hawaiian Marine Sponge in the Genus Myrmekioderma.Drug Transporters and Na+/H+ Exchange Regulatory Factor PSD-95/Drosophila Discs Large/ZO-1 ProteinsSerine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivoSmall-molecule modulators of PXR and CAR.PXR antagonists and implication in drug metabolism.Short hairpin RNA targeting Twist1 suppresses cell proliferation and improves chemosensitivity to cisplatin in HeLa human cervical cancer cells.Role of CAR and PXR in xenobiotic sensing and metabolism.Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.Pregnane X Receptor and Cancer: Context-Specificity is Key.Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer.Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response.Reversal of ATP-binding cassette drug transporter activity to modulate chemoresistance: why has it failed to provide clinical benefit?Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond.Yeast ABC proteins involved in multidrug resistance.Effect of pregnane X receptor expression on drug resistance in breast cancer.Mechanisms and therapeutic potential of inhibiting drug efflux transporters.Microdose-Induced Drug-DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice.Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.Marked differences in the effect of antiepileptic and cytostatic drugs on the functionality of P-glycoprotein in human and rat brain capillary endothelial cell lines.PSP94 contributes to chemoresistance and its peptide derivative PCK3145 represses tumor growth in ovarian cancer.Increased Nanog expression promotes tumor development and Cisplatin resistance in human esophageal cancer cells.GCS overexpression is associated with multidrug resistance of human HCT-8 colon cancer cells.SPA70 is a potent antagonist of human pregnane X receptor.Mechanisms of Drug Resistance in Veterinary Oncology- A Review with an Emphasis on Canine Lymphoma.High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor.GALNT14 Involves the Regulation of Multidrug Resistance in Breast Cancer Cells.
P2860
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P2860
Overcoming drug resistance by regulating nuclear receptors.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Overcoming drug resistance by regulating nuclear receptors.
@ast
Overcoming drug resistance by regulating nuclear receptors.
@en
Overcoming drug resistance by regulating nuclear receptors.
@nl
type
label
Overcoming drug resistance by regulating nuclear receptors.
@ast
Overcoming drug resistance by regulating nuclear receptors.
@en
Overcoming drug resistance by regulating nuclear receptors.
@nl
prefLabel
Overcoming drug resistance by regulating nuclear receptors.
@ast
Overcoming drug resistance by regulating nuclear receptors.
@en
Overcoming drug resistance by regulating nuclear receptors.
@nl
P2860
P1476
Overcoming drug resistance by regulating nuclear receptors.
@en
P2093
Taosheng Chen
P2860
P304
P356
10.1016/J.ADDR.2010.07.008
P407
P577
2010-08-04T00:00:00Z